Nostochopcerol, a new antibacterial monoacylglycerol from the edible cyanobacterium Nostochopsis lobatus

Naoya Oku; Saki Hayashi; Yuji Yamaguchi; Hiroyuki Takenaka; Yasuhiro Igarashi

doi:10.3762/bjoc.19.13

Nostochopcerol, a new antibacterial monoacylglycerol from the edible cyanobacterium Nostochopsis lobatus

Beilstein J Org Chem. 2023 Feb 9:19:133-138. doi: 10.3762/bjoc.19.13. eCollection 2023.

Authors

Naoya Oku¹, Saki Hayashi¹, Yuji Yamaguchi², Hiroyuki Takenaka², Yasuhiro Igarashi¹

Affiliations

¹ Biotechnology Research Center and Department of Biotechnology, Toyama Prefectural University, 5180 Kurokawa, Imizu, Toyama 939-0398, Japan.
² MAC Gifu Research Institute, MicroAlgae Corporation, 4-15 Akebono, Gifu 500-8148, Japan.

Abstract

A new antibacterial 3-monoacyl-sn-glycerol, nostochopcerol (1), was isolated from a cultured algal mass of the edible cyanobacterium Nostochopsis lobatus MAC0804NAN. The structure of compound 1 was established by the analysis of NMR and MS data while its chirality was established by comparison of optical rotation values with synthetically prepared authentics. Compound 1 inhibited the growth of Bacillus subtilis and Staphylococcus aureus at MIC of 50 μg/mL and 100 μg/mL, respectively.

Keywords: Nostochopsis lobatus; antibacterial; cyanobacterium; edible; monoacylglycerol.

Grants and funding

This work was partly supported by JSPS KAKENHI (Grant Number 26660096), President Initiative Fund (Local Issues) FY2015 at Toyama Prefectural University, and MAC collaborative research fund.