The role of miR-128 in cancer development, prevention, drug resistance, and immunotherapy

Hendrik Setia Budi; Laith A Younus; Methaq Hadi Lafta; Sameena Parveen; Hawraa Jabbar Mohammad; Zahraa Haleem Al-Qaim; Mohammed Abed Jawad; Rosario Mireya Romero Parra; Yasser Fakri Mustafa; Firas Rahi Alhachami; Sajad Karampoor; Rasoul Mirzaei

doi:10.3389/fonc.2022.1067974

The role of miR-128 in cancer development, prevention, drug resistance, and immunotherapy

Front Oncol. 2023 Jan 19:12:1067974. doi: 10.3389/fonc.2022.1067974. eCollection 2022.

Affiliations

¹ Department of Oral Biology, Dental Pharmacology, Faculty of Dental Medicine, Universitas Airlangga, Surabaya, Indonesia.
² Department of Clinical Laboratory Sciences, Faculty of Pharmacy, Jabir Ibn, Hayyan Medical University, Al Najaf Al Ashraf, Iraq.
³ Iraqi Ministry of Education, Baghdad, Iraq.
⁴ Department of Maxillofacial Surgery and Diagnostic Sciences, College of Dentistry, Jazan University, Jazan, Saudi Arabia.
⁵ Al-Manara College For Medical Sciences, Maysan, Iraq.
⁶ Department of Anesthesia Techniques , Al-Mustaqbal University College, Hilla, Iraq.
⁷ Al-Nisour University College, Baghdad, Iraq.
⁸ Universidad Continental, Lima, Peru.
⁹ Department of Pharmaceutical Chemistry, College of Pharmacy, University of Mosul, Mosul, Iraq.
¹⁰ Radiology Department, College of Health and Medical Technology, Al-Ayen University, Thi-Qar, Nasiriyah, Iraq.
¹¹ Gastrointestinal and Liver Diseases Research Center, Iran University of Medical Sciences, Tehran, Iran.
¹² Venom and Biotherapeutics Molecules Lab, Medical Biotechnology Department, Biotechnology Research Center, Pasteur Institute of Iran, Tehran, Iran.

Abstract

A growing body of evidence has revealed that microRNA (miRNA) expression is dysregulated in cancer, and they can act as either oncogenes or suppressors under certain conditions. Furthermore, some studies have discovered that miRNAs play a role in cancer cell drug resistance by targeting drug-resistance-related genes or influencing genes involved in cell proliferation, cell cycle, and apoptosis. In this regard, the abnormal expression of miRNA-128 (miR-128) has been found in various human malignancies, and its verified target genes are essential in cancer-related processes, including apoptosis, cell propagation, and differentiation. This review will discuss the functions and processes of miR-128 in multiple cancer types. Furthermore, the possible involvement of miR-128 in cancer drug resistance and tumor immunotherapeutic will be addressed.

Keywords: cancer progression; cancer suppression; chemoresistance; immunotherapy; miR-128.

Publication types

Review