Gut microbiota in pregnancy, please don't change me now

Daniele C Nascimento; Jose C Alves-Filho

doi:10.1016/j.immuni.2023.01.017

Gut microbiota in pregnancy, please don't change me now

Immunity. 2023 Feb 14;56(2):232-234. doi: 10.1016/j.immuni.2023.01.017.

Authors

Daniele C Nascimento¹, Jose C Alves-Filho²

Affiliations

¹ Department of Pharmacology, Ribeirao Preto Medical School, University of Sao Paulo, Ribeirao Preto, Brazil; Center for Research in Inflammatory Diseases, Ribeirao Preto Medical School, University of Sao Paulo, Ribeirao Preto, Brazil. Electronic address: danielecbn@usp.br.
² Department of Pharmacology, Ribeirao Preto Medical School, University of Sao Paulo, Ribeirao Preto, Brazil; Center for Research in Inflammatory Diseases, Ribeirao Preto Medical School, University of Sao Paulo, Ribeirao Preto, Brazil. Electronic address: jcafilho@usp.br.

PMID: 36792568
DOI: 10.1016/j.immuni.2023.01.017

Abstract

Pregnancy predisposes women to develop severe sepsis. However, the mechanisms regulating this remain unclear. In this issue of Immunity, Chen et al. describe the critical role of gut dysbiosis during pregnancy in driving excessive macrophage pyroptosis, increasing susceptibility to sepsis.

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MeSH terms

Dysbiosis
Female
Gastrointestinal Microbiome* / physiology
Humans
Pregnancy
Sepsis*