Attentional modulation of auditory cortical activity in individuals with single-sided deafness

Abstract

Persons with single-sided deafness (SSD) typically complain about the impaired ability to locate sounds and to understand speech within background noise. However, the findings from previous studies suggest that paying attention to sounds could mitigate the degraded spatial and speech-in-noise perception. In the present study, we characterize the pattern of cortical activation depending on the side of deafness, and attentional modulation of neural responses to determine if it can assist better sound processing in people with SSD. For the active listening condition, adult subjects with SSD performed sound localization tasks. On the other hand, they watched movies without attending to speech stimuli during passive listening. The sensor-level global field power of N1 and source-level N1 activation were computed to compare the active- and passive-listening conditions and left- and right-sided deafness. The results show that attentional modulation differs depending on the side of deafness: active listening increased the cortical activity in individuals with left-sided deafness but not in those with right-sided deafness. At the source level, the attentional gain was more apparent in left-sided deafness in that paying attention enhanced brain activation in both hemispheres. In addition, SSD participants with larger cortical activities in the right primary auditory cortex had shorter durations of deafness. Our results indicate that the side of deafness can change top-down attentional processing in the auditory cortical pathway in SSD patients.

Keywords: Attention; Cortical plasticity; Hemispheric lateralization; Single-sided deafness; Sound localization.