Gold nanoparticles-embedded ceria with enhanced antioxidant activities for treating inflammatory bowel disease

Mingyi Li; Jia Liu; Lin Shi; Cheng Zhou; Meizhen Zou; Daan Fu; Ye Yuan; Chundong Yao; Lifang Zhang; Sumei Qin; Miaodeng Liu; Qian Cheng; Zheng Wang; Lin Wang

doi:10.1016/j.bioactmat.2023.01.015

Gold nanoparticles-embedded ceria with enhanced antioxidant activities for treating inflammatory bowel disease

Bioact Mater. 2023 Jan 26:25:95-106. doi: 10.1016/j.bioactmat.2023.01.015. eCollection 2023 Jul.

Authors

Mingyi Li^{1

2

3}, Jia Liu^{1

3}, Lin Shi^{1

2

3}, Cheng Zhou^{1

4

3}, Meizhen Zou^{1

2

3}, Daan Fu^{1

4}, Ye Yuan^{1

4}, Chundong Yao^{1

3}, Lifang Zhang², Sumei Qin^{1

3}, Miaodeng Liu^{1

2

3}, Qian Cheng^{1

2

3}, Zheng Wang^{1

4

3}, Lin Wang^{1

2

3}

Affiliations

¹ Research Center for Tissue Engineering and Regenerative Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China.
² Department of Clinical Laboratory, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China.
³ Hubei Key Laboratory of Regenerative Medicine and Multi-disciplinary Translational Research, Wuhan, 430022, China.
⁴ Department of Gastrointestinal Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science & Technology, Wuhan, 430022, China.

Abstract

The excessive reactive oxygen species (ROS) is a hallmark associated with the initiation and progression of inflammatory bowel disease (IBD), which execrably form a vicious cycle of ROS and inflammation to continually promote disease progression. Here, the gold nanoparticles-embedded ceria nanoparticles (Au/CeO₂) with enhanced antioxidant activities are designed to block this cycle reaction for treating IBD by scavenging overproduced ROS. The Au/CeO₂ with core-shell and porous structure exhibits significantly higher enzymatic catalytic activities compared with commercial ceria nanoparticles, likely due to the effective exposure of catalytic sites, higher content of Ce (III) and oxygen vacancy, and accelerated reduction from Ce (IV) to Ce (III). Being coated with negatively-charged hyaluronic acid, the Au/CeO₂@HA facilitates accumulation in inflamed colon tissues via oral administration, reduces pro-inflammatory cytokines, and effectively alleviates colon injury in colitis mice. Overall, the Au/CeO₂@HA with good biocompatibility is a promising nano-therapeutic for treating IBD.

Keywords: Antioxidant; Ceria nanoparticles; Inflammatory bowel disease; Nanozyme; Reactive oxygen species.