Peptide-based Self-assembly: Design, Bioactive Properties, and Its Applications

Curr Pharm Des. 2023;29(9):640-651. doi: 10.2174/1381612829666230213152259.

Abstract

The self-assembly of peptides is very popular in biomedical fields. Peptide-based assemblies have been used as an ideal candidate for drug/gene delivery, tissue engineering, and antibacterial/anticancer agents. The morphology and structure of peptide self-assembly can be changed by altering the molecular structure and the self-assembly conditions. Engineering peptide assemblies present great potential in medical fields. In this review, the structure and function of peptide self-assembly have been described. Also, the advances in peptide- based self-assembly have been highlighted in biomedical applications, such as drug packaging and delivery, tissue engineering, antibacterial agents, siRNA-targeted delivery and vaccines. Moreover, the challenges and future perspectives of the self-assembly of polypeptides are discussed.

Keywords: Peptides; antibacterial agents; biomedicine; drug delivery; self-assembly; tissue engineering.

Publication types

  • Review
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anti-Bacterial Agents / chemistry
  • Drug Delivery Systems
  • Humans
  • Hydrogels / chemistry
  • Peptides* / chemistry
  • Peptides* / pharmacology
  • Tissue Engineering
  • Vaccines*

Substances

  • Peptides
  • Vaccines
  • Hydrogels
  • Anti-Bacterial Agents