Apolipoprotein C3 induces inflammasome activation only in its delipidated form

Nat Immunol. 2023 Mar;24(3):408-411. doi: 10.1038/s41590-023-01423-2. Epub 2023 Feb 13.

¹ Division of Metabolism, Endocrinology and Nutrition, Department of Medicine, University of Washington Medicine Diabetes Institute, University of Washington, Seattle, WA, USA.
² Department of Medicine, University of California San Diego School of Medicine, La Jolla, CA, USA.
³ Barbara Davis Center for Diabetes, University of Colorado Denver, Aurora, CO, USA.
⁴ Empirico Inc, San Diego, CA, USA.
⁵ Ionis Pharmaceuticals, Carlsbad, CA, USA.
⁶ Division of Metabolism, Endocrinology and Nutrition, Department of Medicine, University of Washington Medicine Diabetes Institute, University of Washington, Seattle, WA, USA. kbornfeldt@medicine.washington.edu.

Abstract

Matters arising regarding the lipidation form of plasma APOC3 that induces an alternative NLRP3 activation pathway.