1-Year Patency of Biorestorative Polymeric Coronary Artery Bypass Grafts in an Ovine Model

Masafumi Ono; Shigetaka Kageyama; Neil O'Leary; Mohammed S El-Kurdi; Jochen Reinöhl; Eric Solien; Richard W Bianco; Mirko Doss; Bart Meuris; Renu Virmani; Martijn Cox; Yoshinobu Onuma; Patrick W Serruys

doi:10.1016/j.jacbts.2022.06.021

1-Year Patency of Biorestorative Polymeric Coronary Artery Bypass Grafts in an Ovine Model

JACC Basic Transl Sci. 2022 Nov 9;8(1):19-34. doi: 10.1016/j.jacbts.2022.06.021. eCollection 2023 Jan.

Authors

Masafumi Ono^{1

2}, Shigetaka Kageyama², Neil O'Leary², Mohammed S El-Kurdi³, Jochen Reinöhl³, Eric Solien⁴, Richard W Bianco⁵, Mirko Doss⁶, Bart Meuris⁷, Renu Virmani⁸, Martijn Cox³, Yoshinobu Onuma², Patrick W Serruys^{2

9}

Affiliations

¹ Amsterdam Universitair Medische Centra, University of Amsterdam, Heart Center, Department of Clinical and Experimental Cardiology, Amsterdam Cardiovascular Sciences, Amsterdam, the Netherlands.
² Department of Cardiology, National University of Ireland, Galway (NUIG), Galway, Ireland.
³ Xeltis BV, Eindhoven, the Netherlands.
⁴ American Preclinical Services, LLC, Minneapolis, Minnesota, USA.
⁵ Experimental Surgical Services, University of Minnesota, Minneapolis, Minnesota, USA.
⁶ Department of Cardiac Surgery, Helios Clinic, Siegburg, Germany.
⁷ Department of Cardiac Surgery, University Hospital Leuven, Leuven, Belgium.
⁸ CVPath Institute, Inc, Gaithersburg, Maryland, USA.
⁹ NHLI, Imperial College London, London, United Kingdom.

Abstract

Many attempts have been made to inhibit or counteract saphenous vein graft (SVG) failure modes; however, only external support for SVGs has gained momentum in clinical utility. This study revealed the feasibility of implantation, and showed good patency out to 12 months of the novel biorestorative graft, in a challenging ovine coronary artery bypass graft model. This finding could trigger the first-in-man trial of using the novel material instead of SVG. We believe that, eventually, this novel biorestorative bypass graft can be one of the options for coronary artery bypass graft patients who have difficulty harvesting SVG.

Keywords: CABG, coronary artery bypass grafting; CPB, cardiopulmonary bypass; IH, intimal hyperplasia; LAD, left anterior descending artery; OCT, optical coherence tomography; QCA, quantitative coronary angiography; QFR, quantitative flow ratio; RVG, restorative vascular graft; SVG, saphenous vein graft; coronary artery bypass graft; coronary artery disease; coronary revascularization; ePTFE, expanded polytetrafluoroethylene; polymeric bypass graft; preclinical model; quantitative flow ratio; restorative vascular graft.