Regulation of mRNA stability contributes to the function of innate lymphoid cells in various diseases

Front Immunol. 2023 Jan 26:14:1118483. doi: 10.3389/fimmu.2023.1118483. eCollection 2023.

Abstract

Innate lymphoid cells (ILCs) are important subsets of innate immune cells that regulate mucosal immunity. ILCs include natural killer cells, innate lymphoid cells-1 (ILC1s), ILC2s, and ILC3s, which have extremely important roles in the immune system. In this review, we summarize the regulation of mRNA stability mediated through various factors in ILCs (e.g., cytokines, RNA-binding proteins, non-coding RNAs) and their roles in mediating functions in different ILC subsets. In addition, we discuss potential therapeutic targets for diseases such as chronic obstructive pulmonary disease, cancer, and pulmonary fibrosis by regulation of mRNA stability in ILCs, which may provide novel directions for future clinical research.

Keywords: ILCs; RBPs; cytokines; mRNA stability; non-coding RNA.

Publication types

  • Review
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Cytokines* / metabolism
  • Immunity, Innate* / physiology
  • Killer Cells, Natural
  • RNA Stability

Substances

  • Cytokines

Grants and funding

This work was supported by grants from the National Natural Science Foundation of China (32170887, 92269110, 32141005 and 32100708), the Chongqing Talent Program of China (cstc2022ycjh-bgzxm0020), the National College Students’ Innovation and Entrepreneurship Training Program (202190035003), and the Undergraduate Research Training Project of Third Military Medical University (Army Medical University) (2021XBK09). The funders had no role in the study design, data analyses, or decision to publish.