Advances in the intraoperative delineation of malignant glioma margin

Shan Jiang; Huihui Chai; Qisheng Tang

doi:10.3389/fonc.2023.1114450

Advances in the intraoperative delineation of malignant glioma margin

Front Oncol. 2023 Jan 26:13:1114450. doi: 10.3389/fonc.2023.1114450. eCollection 2023.

Authors

Shan Jiang¹, Huihui Chai¹, Qisheng Tang¹

Affiliation

¹ Department of Neurosurgery, Huashan Hospital, Fudan University, Shanghai, China.

Abstract

Surgery plays a critical role in the treatment of malignant glioma. However, due to the infiltrative growth and brain shift, it is difficult for neurosurgeons to distinguish malignant glioma margins with the naked eye and with preoperative examinations. Therefore, several technologies were developed to determine precise tumor margins intraoperatively. Here, we introduced four intraoperative technologies to delineate malignant glioma margin, namely, magnetic resonance imaging, fluorescence-guided surgery, Raman histology, and mass spectrometry. By tracing their detecting principles and developments, we reviewed their advantages and disadvantages respectively and imagined future trends.

Keywords: FGS; MRI; Raman histology; glioma; intraoperative; mass spectrometry.

Publication types

Review

Grants and funding

This article was supported by the Shanghai Science and Technology Committee Rising-Star Program(20QA1401900) and National Natural Science Foundation of China (82072020).