H2S Sensors: Synthesis, Optical Properties, and Selected Biomedical Applications under Visible and NIR Light

Dongning Liu; Winston Hessler; Maged Henary

doi:10.3390/molecules28031295

H₂S Sensors: Synthesis, Optical Properties, and Selected Biomedical Applications under Visible and NIR Light

Molecules. 2023 Jan 29;28(3):1295. doi: 10.3390/molecules28031295.

Authors

Dongning Liu¹, Winston Hessler¹, Maged Henary^{1

2}

Affiliations

¹ Department of Chemistry, Georgia State University, Atlanta, GA 30303, USA.
² Center of Diagnostics and Therapeutics, Georgia State University, Atlanta, GA 30303, USA.

Abstract

Hydrogen sulfide (H₂S) is an essential signaling gas within the cell, and its endogenous levels are correlated with various health diseases such as Alzheimer's disease, diabetes, Down's syndrome, and cardiovascular disease. Because it plays such diverse biological functions, being able to detect H₂S quickly and accurately in vivo is an area of heightened scientific interest. Using probes that fluoresce in the near-infrared (NIR) region is an effective and convenient method of detecting H₂S. This approach allows for compounds of high sensitivity and selectivity to be developed while minimizing cytotoxicity. Herein, we report a review on the synthesis, mechanisms, optical properties, and selected biomedical applications of H₂S sensors.

Keywords: FRET; H2S sensor; ICT; PET; TICT; UV/Vis spectroscopy; azide reduction; cyanine dye synthesis.

Publication types

Review

MeSH terms

Fluorescent Dyes*
Hydrogen Sulfide*
Signal Transduction

Substances

Fluorescent Dyes
Hydrogen Sulfide

Grants and funding

RS20201359-02/National Institute of Health