Elucidation of the Role of SMAD4 in Epithelial-Mesenchymal Plasticity: Does It Help to Better Understand the Consequences of DPC4 Inactivation in the Malignant Progression of Pancreatic Ductal Adenocarcinoma?

Hendrik Ungefroren; Björn Konukiewitz; Rüdiger Braun; Ulrich Friedrich Wellner; Tobias Keck; Jens-Uwe Marquardt

doi:10.3390/cancers15030581

Elucidation of the Role of SMAD4 in Epithelial-Mesenchymal Plasticity: Does It Help to Better Understand the Consequences of DPC4 Inactivation in the Malignant Progression of Pancreatic Ductal Adenocarcinoma?

Cancers (Basel). 2023 Jan 18;15(3):581. doi: 10.3390/cancers15030581.

Authors

Hendrik Ungefroren^{1

2

3}, Björn Konukiewitz², Rüdiger Braun⁴, Ulrich Friedrich Wellner⁴, Tobias Keck⁴, Jens-Uwe Marquardt^{1

3}

Affiliations

¹ First Department of Medicine, University Hospital Schleswig-Holstein (UKSH), Campus Lübeck, D-23538 Lübeck, Germany.
² Institute of Pathology, University Hospital Schleswig-Holstein, Campus Kiel, D-24105 Kiel, Germany.
³ Center of Brain, Behavior and Metabolism (CBBM), University of Lübeck, D-23538 Lübeck, Germany.
⁴ Department of Surgery, University Hospital Schleswig-Holstein, Campus Lübeck, D-23538 Lübeck, Germany.

Abstract

Pancreatic ductal adenocarcinoma (PDAC) is the 4th leading cause of cancer-related mortality worldwide, with a 5-year-survival rate below 10% that is the lowest of all cancer types [...].

Publication types

Editorial