Suppressive effects of violet light transmission on myopia progression in a mouse model of lens-induced myopia

Heonuk Jeong; Toshihide Kurihara; Xiaoyan Jiang; Shinichiro Kondo; Yusuke Ueno; Yuki Hayashi; Deokho Lee; Shin-Ichi Ikeda; Kiwako Mori; Hidemasa Torii; Kazuno Negishi; Kazuo Tsubota

doi:10.1016/j.exer.2023.109414

Suppressive effects of violet light transmission on myopia progression in a mouse model of lens-induced myopia

Exp Eye Res. 2023 Mar:228:109414. doi: 10.1016/j.exer.2023.109414. Epub 2023 Feb 9.

Authors

Affiliations

¹ Laboratory of Photobiology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo, 160-8582, Japan; Department of Ophthalmology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo, 160-8582, Japan.
² Laboratory of Photobiology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo, 160-8582, Japan; Department of Ophthalmology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo, 160-8582, Japan. Electronic address: kurihara@z8.keio.jp.
³ Tsubota Laboratory, Inc., 34 Shinanomachi, 304 Toshin Shinanomachi Ekimae Building, Shinjuku-ku, Tokyo, 160-0016, Japan.
⁴ Menicon Co., Ltd., 21-19, Aoi 3, Naka-ku, Nagoya, 460-0006, Japan.
⁵ Department of Ophthalmology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo, 160-8582, Japan.
⁶ Department of Ophthalmology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo, 160-8582, Japan; Tsubota Laboratory, Inc., 34 Shinanomachi, 304 Toshin Shinanomachi Ekimae Building, Shinjuku-ku, Tokyo, 160-0016, Japan. Electronic address: tsubota@tsubota-lab.com.

PMID: 36764596
DOI: 10.1016/j.exer.2023.109414

Abstract

The prevalence of myopia has been steadily increasing for several decades, and this condition can cause extensive medical and economic issues in society. Exposure to violet light (VL), a short wavelength (360-400 nm) of visible light from sunlight, has been suggested as an effective preventive and suppressive treatments for the development and progression of myopia. However, the clinical application of VL remains unclear. In this study, we aimed to investigate the preventive and suppressive effects of VL on myopia progression. Various transmittances of VL (40%, 70%, and 100%) were tested in C57BL/6J mice with lens-induced myopia (LIM). Changes in the refractive error, axial length, and choroid thickness during the 3-week LIM were measured. The myopic shift in refractive error and difference in axial length between the 0 and -30 diopter lens was lessened in a transmission-dependent manner. Choroidal thinning, which was observed in myopic conditions, was suppressed by VL exposure and affected by its transmission. The results suggest that myopia progression can be managed using VL transmittance. Therefore, these factors should be considered for the prevention and treatment of myopia.

Keywords: Axial length; Choroidal thickness; Lens transmission; Myopia; Violet light.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Axial Length, Eye
Choroid
Lens, Crystalline*
Light
Mice
Mice, Inbred C57BL
Myopia* / prevention & control