Cytokine levels in maternal and infant blood after COVID-19 vaccination during pregnancy in comparison with unvaccinated controls

J Reprod Immunol. 2023 Mar:156:103821. doi: 10.1016/j.jri.2023.103821. Epub 2023 Jan 29.

Abstract

The objective of this study was to compare maternal and infant cytokine profiles at delivery among those vaccinated against SARS-CoV-2 during pregnancy to unvaccinated controls. Mother-infant dyads were enrolled in this prospective cohort study, and maternal blood and infant and/or cord blood collected. Samples were analyzed utilizing a LEGENDplex 13-plex human anti-viral response cytokine panel. Maternal IP-10 and IFN-λ2/3 were lower in the vaccinated cohort. In the infants, levels were lower for IL-1β, IFN-λ2/3, and GM-CSF, and higher for IFN-λ1 in the vaccinated cohort. Vaccination against SARS-CoV-2 during pregnancy did not lead to elevations in cytokines in mothers or infants.

Keywords: COVID-19; Cytokines; SARS-CoV-2; Vaccination.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • COVID-19 Vaccines
  • COVID-19* / prevention & control
  • Cytokines*
  • Female
  • Humans
  • Infant
  • Pregnancy
  • Prospective Studies
  • SARS-CoV-2
  • Vaccination

Substances

  • Cytokines
  • COVID-19 Vaccines