Research progress of ophthalmic preparations of immunosuppressants

Ye Liu; Haonan Xu; Na Yan; Zhan Tang; Qiao Wang

doi:10.1080/10717544.2023.2175925

Research progress of ophthalmic preparations of immunosuppressants

Drug Deliv. 2023 Dec;30(1):2175925. doi: 10.1080/10717544.2023.2175925.

Authors

Ye Liu¹, Haonan Xu¹, Na Yan², Zhan Tang^{1

3}, Qiao Wang^{1

3}

Affiliations

¹ School of Pharmacy, Hangzhou Medical College, Hangzhou, Zhejiang, 310013, China.
² Department of Pharmacy, Jin Hua Municipal Maternal and Child Health Care Hospital, Jinhua, Zhejiang, 321000, China.
³ Key Laboratory of Neuropsychiatric Drug Research of Zhejiang Province, Hangzhou Medical College, Hangzhou, Zhejiang, 310013, China.

Abstract

Immune ophthalmopathy is a collection of autoimmune eye diseases. Immunosuppressants are drugs that can inhibit the body's immune response. Considering drug side effects such as hepatorenal toxicity and the unique structure of the eye, incorporating immunosuppressants into ophthalmic nanodrug delivery systems, such as microparticles, nanoparticles, liposomes, micelles, implants, and in situ gels, has the advantages of improving solubility, increasing bioavailability, high eye-target specificity, and reducing side effects. This study reviews recent research and applications of this aspect to provide a reference for the development of an ophthalmic drug delivery system.

Keywords: Immunosuppressant; immune eye disease; nano-delivery system; ophthalmic.

Publication types

Review

MeSH terms

Administration, Ophthalmic
Drug Delivery Systems / methods
Eye
Eye Diseases* / drug therapy
Humans
Immunosuppressive Agents* / pharmacology
Liposomes / pharmacology
Ophthalmic Solutions / chemistry

Substances

Immunosuppressive Agents
Liposomes
Ophthalmic Solutions

Grants and funding

This project is supported by Basic Public Welfare Research Project of Zhejiang Province (No. GF22H128127), National Natural Science Youth Foundation of China (No. 82000864), Science and Technology Projects of Medicine and Health of Zhejiang (No. 2021KY648), The special project of Hangzhou Medical College (No. YS2022009), Science and Technology Project of Jinhua (No. 2021-4-305) and Key Laboratory of Neuropsychiatric Drug Research of Zhejiang Province (2019E10021).