Mousepost 2.0, a major expansion of the resource

Steven Timmermans; Jolien Vandewalle; Claude Libert

doi:10.1093/nar/gkad064

Mousepost 2.0, a major expansion of the resource

Nucleic Acids Res. 2023 Feb 28;51(4):1652-1661. doi: 10.1093/nar/gkad064.

Authors

Steven Timmermans^{1

2}, Jolien Vandewalle^{1

2}, Claude Libert^{1

2}

Affiliations

¹ VIB Center for Inflammation Research, 9052 Ghent, Belgium.
² Department of Biomedical Molecular Biology, Ghent University, Ghent, Belgium.

Abstract

The Mousepost 1.0 online search tool, launched in 2017, allowed to search for variations in all protein-coding gene sequences of 36 sequenced mouse inbred strains, compared to the reference strain C57BL/6J, which could be linked to strain-specific phenotypes and modifier effects. Because recently these genome sequences have been significantly updated and sequences of 16 extra strains added by the Mouse Genomes Project, a profound update, correction and expansion of the Mousepost 1.0 database has been performed and is reported here. Moreover, we have added a new class of protein disturbing sequence polymorphisms (besides stop codon losses, stop codon gains, small insertions and deletions, and missense mutations), namely start codon mutations. The current version, Mousepost 2.0 (https://mousepost.be), therefore is a significantly updated and invaluable tool available to the community and is described here and foreseen by multiple examples.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Codon, Nonsense
Codon, Terminator
Genome*
Mice* / genetics
Mice, Inbred C57BL
Mice, Inbred Strains
Mutation
Software*

Substances

Codon, Nonsense
Codon, Terminator