The research development of STAT3 in hepatic ischemia-reperfusion injury

Hanwen Yang; Pengpeng Zhang; Qiang Wang; Ke Cheng; Yujun Zhao

doi:10.3389/fimmu.2023.1066222

The research development of STAT3 in hepatic ischemia-reperfusion injury

Front Immunol. 2023 Jan 24:14:1066222. doi: 10.3389/fimmu.2023.1066222. eCollection 2023.

Authors

Hanwen Yang¹, Pengpeng Zhang¹, Qiang Wang¹, Ke Cheng¹, Yujun Zhao¹

Affiliation

¹ Engineering and Technology Research Center for Transplantation Medicine of National Health Comission, Third Xiangya Hospital, Central South University, Changsha, China.

Abstract

Ischemia-reperfusion injury (IRI) is a common complication of surgery, which can cause rapid deterioration of the liver function, increase the risk of graft rejection, and seriously affect the prognosis of patients. The signal transducer and activator of transcription 3 (STAT3) protein has been implicated in pathogenesis of IRI. STAT3 influences the mitochondria through multiple pathways and is also involved in apoptosis and other forms of programmed cell death. STAT3 is associated with Janus kinase (JAK), phosphoinositide-3 kinase (PI3K), and heme oxygenase-1 (HO-1) in liver IRI. The STAT3 pathway plays a dual role in IRI as it can also regulate lipid metabolism which may have potential for treating IRI fatty liver. In this review, we summarize research on the function of STAT3 in liver IRI to provide references for its application in the clinic.

Keywords: cell apoptosis; ischemia-reperfusion injury (IRI); liver; mitochondria; signal transducers and activators of transcription3 (STAT3).

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Humans
Janus Kinases / metabolism
Liver / pathology
Reperfusion Injury* / metabolism
STAT3 Transcription Factor* / metabolism
Signal Transduction / physiology

Substances

STAT3 Transcription Factor
Janus Kinases
STAT3 protein, human

Grants and funding

This study was supported by Hunan Provincial Natural Science Foundation of China (2022JJ40759 to PPZ,2022JJ30911 to YZ) and National Natural Science Foundation of China (82100695 to PZ)