High-Grade Prostate Cancer Invading the Vagina: A Case Report of an Unusual Prostate Cancer Diagnosed in a Man with Persistent Mullerian Duct Syndrome

Zaher Bahouth; Mark W Little; Raluca D Badea; Fawaz Musa; Philip J S Charlesworth

doi:10.1159/000529059

High-Grade Prostate Cancer Invading the Vagina: A Case Report of an Unusual Prostate Cancer Diagnosed in a Man with Persistent Mullerian Duct Syndrome

Case Rep Oncol. 2023 Feb 7;16(1):49-54. doi: 10.1159/000529059. eCollection 2023 Jan-Dec.

Authors

Zaher Bahouth¹, Mark W Little², Raluca D Badea³, Fawaz Musa³, Philip J S Charlesworth⁴

Affiliations

¹ Department of Urology, Bnai-Zion Medical Center, Faculty of Medicine, Technion, Haifa, Israel.
² Department of Radiology, Royal Berkshire NHS Trust, Reading, UK.
³ Department of Pathology, Royal Berkshire NHS Trust, Reading, UK.
⁴ The Harold Hopkins Department of Urology, Royal Berkshire NHS Trust, Reading, UK.

Abstract

We report an extremely rare case of locally advanced prostate cancer in a phenotypic male patient with persistent müllerian duct syndrome. The patient underwent a robot-assisted retzius-sparing radical prostatectomy, bilateral pelvic lymph node dissection, radical hysterectomy, vaginectomy, and salpingo-ophorectomy. He was continent at 3 months follow-up. His follow-up PSA has steadily increased up to 1.4 ng/mL 6 months following surgery and his PSMA-PET scan showed bone metastasis with no local recurrence, and androgen deprivation therapy was started along with docetaxel chemotherapy. Prostate cancer in patients with DSD is extremely rare and can manifest itself with a low PSA, although aggressive cancer.

Keywords: Case report; Disorder of sexual development; Persistent mullerian duct syndrome; Prostate cancer.

Publication types

Case Reports

Grants and funding

No funding received.