Novel roles of RNA-binding proteins in drug resistance of breast cancer: from molecular biology to targeting therapeutics

Yinghuan Cen; Letian Chen; Zihao Liu; Qun Lin; Xiaolin Fang; Herui Yao; Chang Gong

doi:10.1038/s41420-023-01352-x

Novel roles of RNA-binding proteins in drug resistance of breast cancer: from molecular biology to targeting therapeutics

Cell Death Discov. 2023 Feb 9;9(1):52. doi: 10.1038/s41420-023-01352-x.

Authors

Yinghuan Cen^#^{1

2}, Letian Chen^#^{1

2}, Zihao Liu^#³, Qun Lin^{1

2}, Xiaolin Fang^{1

2}, Herui Yao^{4

5}, Chang Gong^{6

7}

Affiliations

¹ Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, 510120, Guangzhou, China.
² Breast Tumor Center, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, 510120, Guangzhou, China.
³ Department of Breast and Thyroid Surgery, Shenzhen People's Hospital, The Second Clinical Medical College of Jinan University, The First Affiliated Hospital of Southern University of Science and Technology, 518020, Shenzhen, China.
⁴ Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, 510120, Guangzhou, China. yaoherui@mail.sysu.edu.cn.
⁵ Breast Tumor Center, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, 510120, Guangzhou, China. yaoherui@mail.sysu.edu.cn.
⁶ Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, 510120, Guangzhou, China. gchang@mail.sysu.edu.cn.
⁷ Breast Tumor Center, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, 510120, Guangzhou, China. gchang@mail.sysu.edu.cn.

^# Contributed equally.

Abstract

Therapy resistance remains a huge challenge for current breast cancer treatments. Exploring molecular mechanisms of therapy resistance might provide therapeutic targets for patients with advanced breast cancer and improve their prognosis. RNA-binding proteins (RBPs) play an important role in regulating therapy resistance. Here we summarize the functions of RBPs, highlight their tremendously important roles in regulating therapy sensitivity and resistance and we also reveal current therapeutic approaches reversing abnormal functions of RBPs in breast cancer.

Publication types

Review