Colonizing microbiota is associated with clinical outcomes in diabetic wound healing

Gaofeng Wang; Zhen Lin; Yue Li; Lu Chen; Sashank K Reddy; Zhiqi Hu; L A Garza

doi:10.1016/j.addr.2023.114727

Colonizing microbiota is associated with clinical outcomes in diabetic wound healing

Adv Drug Deliv Rev. 2023 Mar:194:114727. doi: 10.1016/j.addr.2023.114727. Epub 2023 Feb 8.

Authors

Gaofeng Wang¹, Zhen Lin², Yue Li², Lu Chen², Sashank K Reddy³, Zhiqi Hu², L A Garza⁴

Affiliations

¹ Department of Plastic and Aesthetic Surgery, Nanfang Hospital of Southern Medical University, Guangzhou, Guangdong Province 510515, China; Department of Dermatology, Johns Hopkins University School of Medicine, Baltimore, MD 21210, USA. Electronic address: wanggaofeng@smu.edu.cn.
² Department of Plastic and Aesthetic Surgery, Nanfang Hospital of Southern Medical University, Guangzhou, Guangdong Province 510515, China.
³ Department of Dermatology, Johns Hopkins University School of Medicine, Baltimore, MD 21210, USA; Department of Plastic and Reconstructive Surgery, Johns Hopkins School of Medicine, Baltimore, MD 21287, USA.
⁴ Department of Dermatology, Johns Hopkins University School of Medicine, Baltimore, MD 21210, USA; Department of Cell Biology, Johns Hopkins University School of Medicine, Baltimore, MD 21210, USA; Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, MD 21210, USA. Electronic address: LAG@jhmi.edu.

Abstract

With the development of society and the improvement of life quality, more than 500 million people are affected by diabetes. More than 10 % of people with diabetes will suffer from diabetic wounds, and 80 % of diabetic wounds will reoccur, so the development of new diabetic wound treatments is of great importance. The development of skin microbe research technology has gradually drawn people's attention to the complex relationship between microbes and diabetic wounds. Many studies have shown that skin microbes are associated with the outcome of diabetic wounds and can even be used as one of the indicators of wound prognosis. Skin microbes have also been found to have the potential to treat diabetic wounds. The wound colonization of different bacteria can exert opposing therapeutic effects. It is necessary to fully understand the skin microbes in diabetic wounds, which can provide valuable guidance for clinical diabetic wound treatment.

Keywords: Colonizing microbiota; Diabetic wound; Wound microenvironment.

Publication types

Review
Research Support, Non-U.S. Gov't
Research Support, N.I.H., Extramural

MeSH terms

Diabetes Mellitus*
Humans
Microbiota*
Prognosis
Skin
Wound Healing

Abstract

Publication types

MeSH terms

Grants and funding