Static first-minute-frame (FMF) PET imaging after 18F-labeled amyloid tracer injection is correlated to [18F]FDG PET in patients with primary progressive aphasia

Abstract

Objective: To study the correlation between a static PET image of the first-minute-frame (FMF) acquired with ¹⁸F-labeled amyloid-binding radiotracers and brain [¹⁸F]FDG PET in patients with primary progressive aphasia (PPA).

Material and methods: The study cohort includes 17 patients diagnosed with PPA with the following distribution: 9 nonfluent variant PPA, 4 logopenic variant PPA, 1 semantic variant PPA, 3 unclassifiable PPA. Regional SUVRs are extracted from FMFs and their corresponding [¹⁸F]FDG PET images and Pearson's correlation coefficients are calculated.

Results: SUVRs of both images show similar patterns of regional cerebral alterations. Intrapatient correlation analyses result in a mean coefficient of r=0.94±0.06. Regional interpatient correlation coefficients of the study cohort are greater than 0.81. Radiotracer-specific and variant-specific subcohorts show no difference in the similarity between the images.

Conclusions: The static FMF could be a valid alternative to dynamic early-phase amyloid PET proposed in the literature, and a neurodegeneration biomarker for the diagnosis and classification of PPA in amyloid PET studies.

Keywords: Afasia primaria progresiva; Amyloid PET; Biomarcador de neuro-degeneración; Early-phase; Fase precoz; First-minute-frame; Imagen del primer minuto; Neurodegeneration biomarker; PET amiloide; Primary progressive aphasia.