Zn0.4Mg0.6Fe2O4 nanoenzyme: a novel chemo-sensitizer for the chemotherapy treatment of oral squamous cell carcinoma

Liang Chen; Qingmei Kong; Mingxing Tian; Qian Zhang; Chengwan Xia; Chao Deng

doi:10.1039/d2na00750a

Zn_0.4Mg_0.6Fe₂O₄ nanoenzyme: a novel chemo-sensitizer for the chemotherapy treatment of oral squamous cell carcinoma

Nanoscale Adv. 2022 Dec 28;5(3):851-860. doi: 10.1039/d2na00750a. eCollection 2023 Jan 31.

Authors

Liang Chen¹, Qingmei Kong², Mingxing Tian¹, Qian Zhang², Chengwan Xia², Chao Deng³

Affiliations

¹ Department of Oral and Maxillofacial Surgery, Yi Ji Shan Hospital of Wannan Medical College Wuhu Anhui China.
² Department of Oral and Maxillofacial Surgery, Nanjing Stomatology Hospital, Medical School of Nanjing University Nanjing China 2665927917@qq.com.
³ Key Laboratory of Non-coding RNA Transformation Research of Anhui Higher Education, School of Stomatology, Wannan Medical College Anhui China 20120015@wnmc.edu.cn.

Abstract

Hypoxic and acidic environments are the two main components of the microenvironment contributing to the poor efficacy of chemotherapy drugs in the treatment of oral squamous cell carcinoma (OSCC). In this study, we synthesized a series of Zn_1-x Mg _x Fe₂O₄ nanomaterials with enzyme-like properties, including catalase (CAT)-like, peroxidase (POD)-like, and glutathione (GSH)-like activity in an acidic environment. Among them, Zn_0.4Mg_0.6Fe₂O₄ performed the best and effectively increased the efficacy of doxorubicin (DOX) chemotherapy for the treatment of OSCC with reduced cardiotoxicity. Therefore, Zn_0.4Mg_0.6Fe₂O₄ could serve as a novel chemosensitizer in the treatment of OSCC.