The role of tripartite motif-containing 28 in cancer progression and its therapeutic potentials

Yiqing Yang; Shiming Tan; Yaqian Han; Lisheng Huang; Ruiqian Yang; Zifan Hu; Yi Tao; Linda Oyang; Jinguan Lin; Qiu Peng; Xianjie Jiang; Xuemeng Xu; Longzheng Xia; Mingjing Peng; Nayiyuan Wu; Yanyan Tang; Xiaoling Li; Qianjin Liao; Yujuan Zhou

doi:10.3389/fonc.2023.1100134

The role of tripartite motif-containing 28 in cancer progression and its therapeutic potentials

Front Oncol. 2023 Jan 23:13:1100134. doi: 10.3389/fonc.2023.1100134. eCollection 2023.

Authors

Yiqing Yang¹, Shiming Tan¹, Yaqian Han¹, Lisheng Huang^{1

2}, Ruiqian Yang^{1

2}, Zifan Hu^{1

2}, Yi Tao^{1

2}, Linda Oyang¹, Jinguan Lin¹, Qiu Peng¹, Xianjie Jiang¹, Xuemeng Xu¹, Longzheng Xia¹, Mingjing Peng¹, Nayiyuan Wu¹, Yanyan Tang¹, Xiaoling Li¹, Qianjin Liao^{1

3}, Yujuan Zhou^{1

3}

Affiliations

¹ Hunan Key Laboratory of Cancer Metabolism, Hunan Cancer Hospital and the Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, Hunan, China.
² University of South China, Hengyang, Hunan, China.
³ Hunan Key Laboratory of Translational Radiation Oncology, Changsha, Hunan, China.

Abstract

Tripartite motif-containing 28 (TRIM28) belongs to tripartite motif (TRIM) family. TRIM28 not only binds and degrades its downstream target, but also acts as a transcription co-factor to inhibit gene expression. More and more studies have shown that TRIM28 plays a vital role in tumor genesis and progression. Here, we reviewed the role of TRIM28 in tumor proliferation, migration, invasion and cell death. Moreover, we also summarized the important role of TRIM28 in tumor stemness sustainability and immune regulation. Because of the importance of TRIM28 in tumors, TIRM28 may be a candidate target for anti-tumor therapy and play an important role in tumor diagnosis and treatment in the future.

Keywords: E3 ligase; EMT; TRIM28; immune regulation; proliferation; stemness sustainability.

Publication types

Review

Grants and funding

This work was supported in part by grants from the following sources: the National Natural Science Foundation of China (82203233, 82202966, 82173142, 81972636, 81872281), the Natural Science Foundation of Hunan Province (2022JJ80078, 2020JJ5336), the Research Project of Health Commission of Hunan Province (202203034978, 202109031837, 20201020), Key Research and Development Program of Hunan Province (2022SK2051), Hunan Provincial Science and Technology Department (2020TP1018), the Changsha Science and Technology Board (kh2201054), Ascend Foundation of National cancer center (NCC201909B06), and by Hunan Cancer Hospital Climb Plan (ZX2020001-3, YF2020002).