Research progress on rheumatoid arthritis-associated depression

Nian Liu; Weitian Yan; Rong Su; Lin Zhang; Xingqiang Wang; Zhaofu Li; Dongdong Qin; Jiangyun Peng

doi:10.3389/fnbeh.2022.992223

Research progress on rheumatoid arthritis-associated depression

Front Behav Neurosci. 2023 Jan 23:16:992223. doi: 10.3389/fnbeh.2022.992223. eCollection 2022.

Authors

Nian Liu¹, Weitian Yan¹, Rong Su², Lin Zhang¹, Xingqiang Wang², Zhaofu Li³, Dongdong Qin³, Jiangyun Peng²

Affiliations

¹ First Clinical Medical School, Yunnan University of Chinese Medicine, Kunming, China.
² Rheumatism Center, Yunnan Provincial Hospital of Traditional Chinese Medicine, Kunming, China.
³ Basic Medical School, Yunnan University of Chinese Medicine, Kunming, China.

Abstract

Depression is an independent mood disorder and one of the most common comorbidities of rheumatoid arthritis (RA). Growing evidence suggests that there is two-way regulation between RA and depression, resulting in a vicious cycle of RA, depression, poor outcomes, and disease burden. The rising prevalence of RA-associated depression warrants a re-examination of the relationships between them. Here we provide an overview of the etiology and pathological mechanisms of RA-associated depression, and recent advances in treatment with biologics, which will facilitate the development of new and effective prevention and treatment strategies.

Keywords: biological therapies; depression; etiology; pathology; research progress; rheumatoid arthritis.

Publication types

Review

Grants and funding

This study was supported by the National Natural Science Foundation of China (No. 81960863, No. 82160901) and Yunnan Clinical Research Center for Rheumatism of Traditional Chinese Medicine (No. 202002AA310005).