γδ T cells unveil invisible tumors

Hui-Fern Koay; Lydia Lynch

doi:10.1016/j.it.2023.01.011

γδ T cells unveil invisible tumors

Trends Immunol. 2023 Mar;44(3):159-161. doi: 10.1016/j.it.2023.01.011. Epub 2023 Feb 7.

Authors

Hui-Fern Koay¹, Lydia Lynch²

Affiliations

¹ Department of Microbiology and Immunology at the Peter Doherty Institute for Infection and Immunity, The University of Melbourne, Melbourne, VIC, Australia.
² Department of Medicine, Brigham and Women's Hospital, Boston, Harvard Medical School, Boston, MA, USA. Electronic address: llynch@bwh.harvard.edu.

PMID: 36754745
DOI: 10.1016/j.it.2023.01.011

Abstract

Tumors can evade conventional T cell recognition by rendering the HLA class I antigen presentation system defective. In a recent study, de Vries et al. reveal γδ T cells as key contributors to the efficacy of immune checkpoint blockade (ICB) against HLA-I-silenced cancers, highlighting a novel layer of surveillance against immune escape by tumors.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

MeSH terms

Histocompatibility Antigens Class I
Humans
Neoplasms*
T-Lymphocytes

Substances

Histocompatibility Antigens Class I

Grants and funding

R01 AI134861/AI/NIAID NIH HHS/United States