Phytoestrogens, novel dietary supplements for breast cancer

Biomed Pharmacother. 2023 Apr:160:114341. doi: 10.1016/j.biopha.2023.114341. Epub 2023 Feb 6.

Abstract

While endocrine therapy is considered as an effective way to treat breast cancer, it still faces many challenges, such as drug resistance and individual discrepancy. Therefore, novel preventive and therapeutic modalities are still in great demand to decrease the incidence and mortality rate of breast cancer. Numerous studies suggested that G protein-coupled estrogen receptor (GPER), a membrane estrogen receptor, is a potential target for breast cancer prevention and treatment. It was also shown that not only endogenous estrogens can activate GPERs, but many phytoestrogens can also function as selective estrogen receptor modulators (SERMs) to interact GPERs. In this review, we discussed the possible mechanisms of GPERs pathways and shed a light of developing novel phytoestrogens based dietary supplements against breast cancers.

Keywords: Breast cancer; G protein-coupled estrogen receptor; Phytoestrogens; Signing pathway.

Publication types

  • Review

MeSH terms

  • Breast Neoplasms* / drug therapy
  • Breast Neoplasms* / metabolism
  • Breast Neoplasms* / prevention & control
  • Dietary Supplements
  • Estrogens / metabolism
  • Female
  • Humans
  • Phytoestrogens / pharmacology
  • Phytoestrogens / therapeutic use
  • Receptors, Estrogen / metabolism
  • Selective Estrogen Receptor Modulators / therapeutic use

Substances

  • Phytoestrogens
  • Receptors, Estrogen
  • Estrogens
  • Selective Estrogen Receptor Modulators