Dissemination of Antibiotic Resistance Genes Among Patients with Diarrhea - Freetown, Sierra Leone, 2018

Xia Chen; Enmin Zhang; Michael K Abdulai; Alie Brima Tia; Esther Debora Ngegba; Jianhai Yin; Songtao Xu; Lili Wang; Xiaoping Dong; Doris Harding; Biao Kan

doi:10.46234/ccdcw2022.221

Dissemination of Antibiotic Resistance Genes Among Patients with Diarrhea - Freetown, Sierra Leone, 2018

China CDC Wkly. 2022 Dec 9;4(49):1093-1096. doi: 10.46234/ccdcw2022.221.

Authors

Xia Chen^{1

2}, Enmin Zhang^{1

2}, Michael K Abdulai², Alie Brima Tia², Esther Debora Ngegba², Jianhai Yin^{3

2}, Songtao Xu^{4

2}, Lili Wang⁵, Xiaoping Dong^{4

5}, Doris Harding⁶, Biao Kan^{1

2}

Affiliations

¹ State Key Laboratory of Infectious Disease Prevention and Control, National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing Municipality, China.
² Sierra Leone-China Friendship Biological Safety Laboratory, Chinese Center for Disease Control and Prevention, Freetown, Sierra Leone and Beijing Municipality, China.
³ National Institute of Parasitic Diseases, Chinese Center for Disease Control and Prevention; Chinese Center for Tropical Diseases Research, Shanghai Municipality, China.
⁴ National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing Municipality, China.
⁵ Center for Global Public Health, Chinese Center for Disease Control and Prevention, Beijing Municipality, China.
⁶ Ministry of Health and Sanitation, Freetown, Sierra Leone.

Abstract

What is already known about this topic?: Antibiotic resistance (AR) is a serious public health threat worldwide. However, the AR and antibiotic resistance genes (ARGs) data from West Africa, especially from Sierra Leone, are limited.

What is added by this report?: The study revealed ARGs' common dissemination, and multiplex antibiotic resistance genes in one sample. Genes bla _NDM and bla _OXA _-48-like were first discovered in Sierra Leone.

What are the implications for public health practice?: Basic information is provided for AR research and surveillance and highlights that effective AR surveillance among diarrhea patients is necessary for Sierra Leone and West Africa.

Keywords: Antibiotic Resistance Genes; Diarrhea; Dissemination.

Copyright and License information: Editorial Office of CCDCW, Chinese Center for Disease Control and Prevention 2022.

Grants and funding

Supported by the National Key Research and Development Program of China (2020YFE0205700, 2022YFC2303900), the major projects of the National Natural Science Foundation of China (22193064)