Prevalence of High-Risk Human Papillomavirus in Cervical Intraepithelial Neoplasia in the Pre-Vaccine Era - China, 2017-2018

Heling Bao; Weihong Chen; Xiaosong Zhang; Hui Bi; Yun Zhao; Liwen Fang; Shu Cong; Feng Tan; Linhong Wang

doi:10.46234/ccdcw2022.218

Prevalence of High-Risk Human Papillomavirus in Cervical Intraepithelial Neoplasia in the Pre-Vaccine Era - China, 2017-2018

China CDC Wkly. 2022 Dec 2;4(48):1083-1087. doi: 10.46234/ccdcw2022.218.

Authors

Heling Bao^{1

2}, Weihong Chen³, Xiaosong Zhang⁴, Hui Bi⁴, Yun Zhao⁵, Liwen Fang², Shu Cong², Feng Tan³, Linhong Wang²

Affiliations

¹ Institute of Medical Information, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China.
² National Center for Chronic and Non-communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, China.
³ Chinese Center for Disease Control and Prevention, Beijing, China.
⁴ Department of Obstetrics and Gynecology, Peking University First Hospital, Beijing, China.
⁵ Department of Obstetrics and gynecology, Peking University People's Hospital, Beijing, China.

Abstract

What is already known about this topic?: Human papillomavirus (HPV) type-specific strategies play a key role in the prevention of cervical intraepithelial neoplasia (CIN), but evidence on the HPV type-specific prevalence in CIN is limited.

What is added by this report?: This multicentric study estimates the prevalence of high-risk HPV types in CIN cases and the associations of HPV infection patterns with high-grade CIN in China in 2017-2018.

What are the implications for public health practice?: Population-based prevention strategies should give preference to HPV-16 and 18, and strategies for non-16/18 high-risk HPV are essential for the elimination of cervical cancer.

Keywords: Cervical Intraepithelial Neoplasia; Papillomavirus; Prevalence.

Copyright and License information: Editorial Office of CCDCW, Chinese Center for Disease Control and Prevention 2022.

Grants and funding

Chinese Association of Maternal and Child Health Studies (2017AMCHS006) and National Natural Science Foundation of China (81903328)