Objective: To investigate the influence factors of lead in whole blood in the German External Quality Assessment Scheme(G-EQUAS) biological materials by inductively coupled plasma mass spectrometry(ICP-MS) from 2018 to 2020.
Methods: ICP-MS was used to determine lead in whole blood of G-EQUAS by optimizing the reaction gas mode, sample dilution ratio, internal standard element, isotope and so on, analyzed the result.
Results: This study indicated that selection of internal standard elements, isotopes, matrix effect and physical effect may affect the accuracy of ICP-MS determination of lead in biological samples.
Conclusion: Avoided the factors that may affect the result when determining lead in whole blood by ICP-MS.
Keywords: blood; inductively coupled plasma mass spectrometry; lead.