Combining analytical epidemiology and genomic surveillance to identify risk factors associated with the spread of antimicrobial resistance in Salmonella enterica subsp. enterica serovar Heidelberg

Benjamin M Hetman; David L Pearl; Dillon O R Barker; James Robertson; John H E Nash; Richard Reid-Smith; Agnes Agunos; Catherine Carrillo; Edward Topp; Gary Van Domselaar; E Jane Parmley; Amrita Bharat; Michael Mulvey; Vanessa Allen; Eduardo N Taboada

doi:10.1099/mgen.0.000891

Combining analytical epidemiology and genomic surveillance to identify risk factors associated with the spread of antimicrobial resistance in Salmonella enterica subsp. enterica serovar Heidelberg

Microb Genom. 2022 Nov;8(11):mgen000891. doi: 10.1099/mgen.0.000891.

Authors

Benjamin M Hetman¹, David L Pearl¹, Dillon O R Barker², James Robertson³, John H E Nash³, Richard Reid-Smith^{1

4}, Agnes Agunos⁴, Catherine Carrillo⁵, Edward Topp⁶, Gary Van Domselaar², E Jane Parmley¹, Amrita Bharat², Michael Mulvey², Vanessa Allen^{7

8}, Eduardo N Taboada²

Affiliations

¹ Department of Population Medicine, Ontario Veterinary College, University of Guelph, Guelph, Ontario, Canada.
² National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Manitoba, Canada.
³ National Microbiology Laboratory, Public Health Agency of Canada, Guelph, Ontario, Canada.
⁴ Centre for Foodborne, Environmental and Zoonotic Infectious Diseases, Public Health Agency of Canada, Guelph, Ontario, Canada.
⁵ Ottawa Laboratory (Carling), Canadian Food Inspection Agency, Ottawa, Ontario, Canada.
⁶ London Research and Development Centre, Agriculture and Agri-Food Canada, London, Ontario, Canada; Department of Biology, University of Western Ontario, London, Ontario, Canada.
⁷ Public Health Ontario Laboratory, Toronto, Ontario, Canada.
⁸ Present address: Department of Laboratory Medicine and Pathobiology, University of Toronto, Ontario, Toronto, Canada.

Abstract

Antimicrobial resistance (AMR) has become a critical threat to public health worldwide. The use of antimicrobials in food and livestock agriculture, including the production of poultry, is thought to contribute to the dissemination of antibiotic resistant bacteria (ARB) and the genes and plasmids that confer the resistant phenotype (ARG). However, the relative contribution of each of these processes to the emergence of resistant pathogens in poultry production and their potential role in the transmission of resistant pathogens in human infections, requires a deeper understanding of the dynamics of ARB and ARG in food production and the factors involved in the increased risk of transmission.

Keywords: antimicrobial resistance; genomic epidemiology; salmonella; surveillance; whole genome sequencing.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Angiotensin Receptor Antagonists
Angiotensin-Converting Enzyme Inhibitors
Animals
Anti-Bacterial Agents* / pharmacology
Drug Resistance, Bacterial / genetics
Drug Resistance, Multiple, Bacterial / genetics
Genomics
Humans
Poultry / microbiology
Risk Factors
Salmonella enterica* / genetics
Serogroup

Substances

Anti-Bacterial Agents
Angiotensin Receptor Antagonists
Angiotensin-Converting Enzyme Inhibitors

Supplementary concepts

Salmonella enterica subsp. enterica