Theranostic Nanoprobes with Aggregation-Induced NIR-II Emission: from Molecular Design to Biomedical Application

Yajing Jiang; Linlin Zhu; Wenbo Wu

doi:10.1002/cbic.202200777

Theranostic Nanoprobes with Aggregation-Induced NIR-II Emission: from Molecular Design to Biomedical Application

Chembiochem. 2023 Apr 17;24(8):e202200777. doi: 10.1002/cbic.202200777. Epub 2023 Mar 22.

Authors

Yajing Jiang¹, Linlin Zhu¹, Wenbo Wu¹

Affiliation

¹ Department of Chemistry, Institute of Molecular Aggregation Science, Tianjin University, Tianjin, 300072, P. R. China.

PMID: 36748168
DOI: 10.1002/cbic.202200777

Abstract

The development of fluorophores with other powerful features has received much attention for the diagnosis and treatment of diseases. Nanoprobes (NPs) with aggregation-induced emission (AIE) have demonstrated superior performance in deeper penetration depth with better resolution, higher signal-to-noise ratio, and lower side effects in the second near-infrared window (NIR-II, 1000-1700 nm) than in any other range. Herein, the latest advances in NIR-II AIE NPs in cancer theranostics are summarized. In particular, we focus on the design of multifunctional AIE agents with both strong NIR-II emission and effective photothermal conversion or reactive oxygen species (ROS) production, as well as their translational biomedical applications, including imaging diagnosis, image-guided surgery, and image-guided phototherapy, etc. At the end of this review, the opportunities and challenges of this field are also discussed.

Keywords: aggregation-induced emission; nanoprobes; phototherapy; the second near-infrared window; theranostics.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Humans
Nanoparticles* / therapeutic use
Neoplasms* / diagnostic imaging
Neoplasms* / therapy
Optical Imaging
Phototherapy
Precision Medicine
Theranostic Nanomedicine / methods