Reconstruction of Abdominal Wall Defect with Composite Scaffold of 3D Printed ADM/PLA in a Rat Model

Macromol Biosci. 2023 Apr;23(4):e2200521. doi: 10.1002/mabi.202200521. Epub 2023 Feb 12.

Abstract

Abdominal wall defects are a frequently occurring condition in surgical practice. The most important are material structure and biocompatibility. In this study, polylactic acid (PLA) mesh composited with a 3D printing of acellular dermal matrix (ADM) material is used to repair abdominal wall defects. The results show that the adhesion score of ADM/PLA composite scaffolds is smaller than PLA meshes. Immunohistochemical assessment reveals that the ADM/PLA composite scaffold can effectively reduce the inflammatory response at the contact surface between the meshes and the abdominal organs. And the ADM/PLA composite scaffold can effectively reduce the expression levels of the inflammation-related factors IL-6 and IL-10. In addition, the ADM/PLA composite scaffold repair is rich in the expression levels of tissue regeneration-related factors vascular endothelial growth factor and transforming growth factor β. Thus, ADM/PLA composite scaffolds can effectively reduce surrounding inflammation to effectively promote the repair of abdominal wall defects.

Keywords: 3D print; abdominal wall defects; acellular dermal matrix, regeneration.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Abdominal Wall* / surgery
  • Acellular Dermis*
  • Animals
  • Polyesters
  • Printing, Three-Dimensional
  • Rats
  • Tissue Scaffolds / chemistry
  • Vascular Endothelial Growth Factor A

Substances

  • poly(lactide)
  • Vascular Endothelial Growth Factor A
  • Polyesters