Overview of the role and action mechanism of microRNA-128 in viral infections

Shadia Hamoud Alshahrani; Ameer A Alameri; Fitriani Kahar; Andrés Alexis Ramírez-Coronel; Rasha Fadhel Obaid; Fahad Alsaikhan; Rahman S Zabibah; Qutaiba A Qasim; Farag M A Altalbawy; Yasser Fakri Mustafa; Rasoul Mirzaei; Sajad Karampoor

doi:10.1016/j.micpath.2023.106020

Overview of the role and action mechanism of microRNA-128 in viral infections

Microb Pathog. 2023 Mar:176:106020. doi: 10.1016/j.micpath.2023.106020. Epub 2023 Feb 4.

Affiliations

¹ Medical Surgical Nursing Department, King Khalid University, Almahala, Khamis Mushate, Saudi Arabia.
² Department of Chemistry, University of Babylon, Babylon, Iraq.
³ Medic Technology Laboratory, Poltekkes Kemenkes Semarang, Indonesia.
⁴ National University of Education, Azogues, Ecuador; Catholic University of Cuenca, Azogues Campus, Ecuador; University of Palermo, Buenos Aires, Argentina; CES University, Colombia, Azogues, Ecuador.
⁵ Department of Biomedical Engineering, Al-Mustaqbal University College, Babylon, Iraq.
⁶ College of Pharmacy, Prince Sattam Bin Abdulaziz University, Alkharj, Kingdom of Saudi Arabia.
⁷ Medical Laboratory Technology Department, College of Medical Technology, The Islamic University, Najaf, Iraq.
⁸ College of Pharmacy, Al-Ayen University, Thi-Qar, Iraq.
⁹ National Institute of Laser Enhanced Sciences (NILES), Cairo University, Giza 12613, Egypt; Department of Chemistry, University College of Duba, Tabuk University, Duba 71911, Saudi Arabia.
¹⁰ Department of Pharmaceutical Chemistry, College of Pharmacy, University of Mosul, Mosul 41001, Iraq.
¹¹ Venom and Biotherapeutics Molecules Lab, Medical Biotechnology Department, Biotechnology Research Center, Pasteur Institute of Iran, Tehran, Iran. Electronic address: rasul.micro92@gmail.com.
¹² Gastrointestinal and Liver Diseases Research Center, Iran University of Medical Sciences, Tehran, Iran. Electronic address: karampour.s@iums.ac.ir.

PMID: 36746316
DOI: 10.1016/j.micpath.2023.106020

Abstract

Recently in vivo and in vitro studies have provided evidence establishing the significance of microRNAs (miRNAs) in both physiological and pathological conditions. In this regard, the role of miRNA-128 (miR-128) in health and diseases has been found, and its critical regulatory role in the context of some viral diseases has been recently identified. For instance, it has been found that miR-128 can serve as an antiviral mediator and significantly limit the replication and dissemination of human immunodeficiency virus type 1 (HIV-1). Besides, it has been noted that poliovirus receptor-related 4 (PVRL4) is post-transcriptionally regulated by miR-128, representing possible miRNA targets that can modulate measles virus infection. Of note, the downregulation of seminal exosomes eca-miR-128 is associated with the long-term persistence of Equine arteritis virus (EAV) in the reproductive tract, and this particular miRNA is a putative regulator of chemokine ligand 16 (C-X-C motif) as determined by target prediction analysis. In this review, the latest information on the role and action mechanism of miR-128 in viral infections will be summarized and discussed in detail.

Keywords: Equine arteritis virus; Hepatitis C virus; Herpesvirus of Turkey; Human immunodeficiency virus type 1; Inflammation; Marek's disease; Measles virus; miR-128.

Publication types

Review

MeSH terms

Animals
Down-Regulation
Genitalia
Horses
Humans
MicroRNAs* / genetics
Virus Diseases*
Virus Replication

Substances

MicroRNAs
MIRN128 microRNA, human