RNA-binding proteins in degenerative joint diseases: A systematic review

Ageing Res Rev. 2023 Apr:86:101870. doi: 10.1016/j.arr.2023.101870. Epub 2023 Feb 4.

Abstract

RNA-binding proteins (RBPs), which are conserved proteins comprising multiple intermediate sequences, can interact with proteins, messenger RNA (mRNA) of coding genes, and non-coding RNAs to perform different biological functions, such as the regulation of mRNA stability, selective polyadenylation, and the management of non-coding microRNA (miRNA) synthesis to affect downstream targets. This article will highlight the functions of RBPs, in degenerative joint diseases (intervertebral disc degeneration [IVDD] and osteoarthritis [OA]). It will reviews the latest advancements on the regulatory mechanism of RBPs in degenerative joint diseases, in order to understand the pathophysiology, early diagnosis and treatment of OA and IVDD from a new perspective.

Keywords: Degenerative joint diseases; Intervertebral disc degeneration; Osteoarthritis; RNA-binding proteins.

Publication types

  • Systematic Review
  • Review
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Humans
  • Intervertebral Disc Degeneration* / metabolism
  • Joint Diseases*
  • RNA, Messenger / genetics
  • RNA-Binding Proteins / genetics
  • RNA-Binding Proteins / metabolism
  • Signal Transduction

Substances

  • RNA, Messenger
  • RNA-Binding Proteins