Efficacy of thrombus aspiration in cardiogenic shock complicating acute myocardial infarction and high thrombus burden
Rev Esp Cardiol (Engl Ed). 2023 Sep;76(9):719-728.
doi: 10.1016/j.rec.2023.01.009.
Epub 2023 Feb 4.
[Article in
English,
Spanish]
Authors
Woochan Kwon
1
, Ki Hong Choi
1
, Jeong Hoon Yang
2
, Yu Jin Chung
1
, Taek Kyu Park
1
, Joo Myung Lee
1
, Young Bin Song
1
, Joo-Yong Hahn
1
, Seung-Hyuk Choi
1
, Chul-Min Ahn
3
, Cheol Woong Yu
4
, Ik Hyun Park
5
, Woo Jin Jang
6
, Hyun-Joong Kim
7
, Jang-Whan Bae
8
, Sung Uk Kwon
9
, Hyun-Jong Lee
10
, Wang Soo Lee
11
, Jin-Ok Jeong
12
, Sang-Don Park
13
, Hyeon-Cheol Gwon
1
Affiliations
- 1 Division of Cardiology, Department of Medicine, Heart Vascular Stroke Institute, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.
- 2 Division of Cardiology, Department of Medicine, Heart Vascular Stroke Institute, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea. Electronic address: jhysmc@gmail.com.
- 3 Division of Cardiology, Severance Cardiovascular Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea.
- 4 Division of Cardiology, Department of Internal Medicine, Korea University Anam Hospital, Seoul, Republic of Korea.
- 5 Department of Cardiology, Samsung Changwon Hospital, Sungkyunkwan University School of Medicine, Changwon, Republic of Korea.
- 6 Department of Cardiology, Ewha Woman's University Seoul Hospital, Ewha Woman's University School of Medicine, Seoul, Republic of Korea.
- 7 Division of Cardiology, Department of Medicine, Konkuk University Medical Center, Seoul, Republic of Korea.
- 8 Department of Internal Medicine, Chungbuk National University College of Medicine, Cheongju, Republic of Korea.
- 9 Division of Cardiology, Department of Internal Medicine, Ilsan Paik Hospital, University of Inje College of Medicine, Seoul, Republic of Korea.
- 10 Division of Cardiology, Department of Medicine, Sejong General Hospital, Bucheon, Republic of Korea.
- 11 Division of Cardiology, Department of Medicine, Chung-Ang University Hospital, Seoul, Republic of Korea.
- 12 Division of Cardiology, Department of Internal Medicine, Chungnam National University Hospital, Daejeon, Republic of Korea.
- 13 Division of Cardiology, Department of Medicine, Inha University Hospital, Incheon, Republic of Korea.
Abstract
Introduction and objectives:
Current guidelines do not recommend routine thrombus aspiration in acute myocardial infarction (AMI) because no benefits were observed in previous randomized trials. However, there are limited data in cardiogenic shock (CS) complicating AMI.
Methods:
We included 575 patients with AMI complicated by CS. The participants were stratified into the TA and no-TA groups based on use of TA. The primary outcome was a composite of 6-month all-cause death or heart failure rehospitalization. The efficacy of TA was additionally assessed based on thrombus burden (grade I-IV vs V).
Results:
No significant difference was found in in-hospital death (28.9% vs 33.5%; P=.28), or 6-month death, or heart failure rehospitalization (32.4% vs 39.4%; HRadj: 0.80; 95%CI, 0.59-1.09; P=.16) between the TA and no-TA groups. However, in 368 patients with a higher thrombus burden (grade V), the TA group had a significantly lower risk of 6-month all-cause death or heart failure rehospitalization than the no-TA group (33.4% vs 46.3%; HRadj: 0.59; 95%CI, 0.41-0.85; P=.004), with significant interaction between thrombus burden and use of TA for primary outcome (adjusted Pint=.03).
Conclusions:
Routine use of TA did not reduce short- and mid-term adverse clinical outcomes in patients with AMI complicated by CS. However, in select patients with a high thrombus burden, the use of TA might be associated with improved clinical outcomes. The study was registered at ClinicalTrials.gov (Identifier: NCT02985008).
Keywords:
Cardiogenic shock; Coronary thrombosis; Infarto de miocardio; Myocardial infarction; Shock cardiogénico; Thrombectomy; Trombectomía; Trombosis coronaria.
Copyright © 2023 Sociedad Española de Cardiología. Published by Elsevier España, S.L.U. All rights reserved.
MeSH terms
-
Coronary Thrombosis* / complications
-
Coronary Thrombosis* / diagnosis
-
Coronary Thrombosis* / therapy
-
Heart Failure* / complications
-
Hospital Mortality
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Humans
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Myocardial Infarction* / complications
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Percutaneous Coronary Intervention* / adverse effects
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Shock, Cardiogenic / etiology
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Shock, Cardiogenic / therapy
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Thrombectomy
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Treatment Outcome
Associated data
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ClinicalTrials.gov/NCT02985008