Т1 mapping of rat lungs in 19 F MRI using octafluorocyclobutane

Abstract

Purpose: To demonstrate the feasibility of using octafluorocyclobutane (OFCB, c-C₄ F₈ ) for T₁ mapping of lungs in ¹⁹ F MRI.

Methods: The study was performed at 7 T in three healthy rats and three rats with pulmonary hypertension. To increase the sensitivity of ¹⁹ F MRI, a bent-shaped RF coil with periodic metal strips structure was used. The double flip angle method was used to calculate normalized transmitting RF field (B_1n ⁺ ) maps and for correcting T₁ maps built with the variable flip angle (VFA) method. The ultrashort TE pulse sequence was applied for acquiring MR images throughout the study.

Results: The dependencies of OFCB relaxation times on its partial pressure in mixtures with oxygen, air, helium, and argon were obtained. T₁ of OFCB linearly depended on its partial pressure with the slope of about 0.35 ms/kPa in the case of free diffusion. RF field inhomogeneity leads to distortion of T₁ maps built with the VFA method, and therefore to high standard deviation of T₁ in these maps. To improve the accuracy of the T₁ maps, the B_1n ⁺ maps were applied for VFA correction. This contributed to a 2-3-fold decrease in the SD of T₁ values in the corresponding maps compared with T₁ maps calculated without the correction. Three-dimensional T₁ maps were obtained, and the mean T₁ in healthy rat lungs was 35 ± 10 ms, and in rat lungs with pulmonary hypertension - 41 ± 9 ms.

Conclusion: OFCB has a spin-rotational relaxation mechanism and can be used for ¹⁹ F T₁ mapping of lungs. The calculated OFCB maps captured ventilation defects induced by edema.

Keywords: T 2 * $$ {\mathrm{T}}_2^{\ast } $$ mapping; 19F MRI; T1 mapping; UTE; lung imaging; octafluorocyclobutane.