Two new sarasinosides from marine sponge Petrosia nigricans

Rohaidah L Mama; Chona D Gelani; Jan Mart T Daluz; Mylene M Uy; Emi Ohta; Shinji Ohta

doi:10.1080/14786419.2023.2175359

Two new sarasinosides from marine sponge Petrosia nigricans

Nat Prod Res. 2023 Feb 6:1-9. doi: 10.1080/14786419.2023.2175359. Online ahead of print.

Authors

Rohaidah L Mama¹, Chona D Gelani¹, Jan Mart T Daluz², Mylene M Uy¹, Emi Ohta³, Shinji Ohta³

Affiliations

¹ Department of Chemistry, Mindanao State University-Iligan Institute of Technology, Iligan City, Philippines.
² Premier Research Institute of Science and Mathematics, Mindanao State University-Iligan Institute of Technology, Iligan City, Philippines.
³ Graduate School of Integrated Sciences for Life, Hiroshima University, Higashi-Hiroshima, Japan.

PMID: 36744713
DOI: 10.1080/14786419.2023.2175359

Abstract

Two new sarasinosides designated as 5,8-epoxysarasinoside (1) and 8,9-epoxysarasinoside (2) and four known sarasinosides were isolated from marine sponge Petrosia nigricans, collected off the coast of Lipata, Surigao City, Philippines (9°49' North, 125°27' East). The structures were determined through extensive 2D NMR spectroscopy and HRMS. Both compounds exhibited low cytotoxicity against the HCT116 (colon) and A549 (lung) cancer cell lines.

Keywords: Marine sponge; Petrosia nigricans; sarasinoside; triterpenoid saponin.