A rare case report of waldenström macroglobulinemia converted to serum low IgM

Yuan Xiang; Shi-Qiang Fang; Yi-Wen Liu; Hui Wang; Zhong-Xin Lu

doi:10.3389/fgene.2022.1051917

A rare case report of waldenström macroglobulinemia converted to serum low IgM

Front Genet. 2023 Jan 19:13:1051917. doi: 10.3389/fgene.2022.1051917. eCollection 2022.

Authors

Yuan Xiang¹, Shi-Qiang Fang¹, Yi-Wen Liu¹, Hui Wang¹, Zhong-Xin Lu¹

Affiliation

¹ Department of Medical Laboratory, Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.

Abstract

Waldenström Macroglobulinemia (WM) is a rare chronic lymphoproliferative disease, accounting for less than 2% of hematological malignancies. It is characterized by plasma cytoid lymphocyte infiltration in bone marrow and abnormal increase of monoclonal IgM in peripheral blood. Only 5%-10% of cases of WM secrete monoclonal IgG and IgA components or do not secrete monoclonal long immunoglobulin. This case is the first to report of serum protein recombination from lgM and Igkappa band mutation to abnormal lgG and Igkappa band after 6 years of treatment in a male patient with WM.

Keywords: abnormal increase of IgM; mutation; rare chronic lymphoproliferative; waldenström macroglobulinemia; waldenström macroglobulinemia/lymphoplasmacytoid lymphoma.

Publication types

Case Reports

Grants and funding

This work was supported by Wuhan Municipal Health Commission Project (Project no. WX21Q49), Hubei Natural Science Foundation (2021CFB230), and by one local grant from The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology to YX.