Role of transcription factors in apoptotic cells clearance

Yuqiong Gao; Yating Jiao; Xiaoyi Gong; Jie Liu; Hui Xiao; Qian Zheng

doi:10.3389/fcell.2023.1110225

Role of transcription factors in apoptotic cells clearance

Front Cell Dev Biol. 2023 Jan 19:11:1110225. doi: 10.3389/fcell.2023.1110225. eCollection 2023.

Authors

Yuqiong Gao¹, Yating Jiao¹, Xiaoyi Gong¹, Jie Liu¹, Hui Xiao¹, Qian Zheng¹

Affiliation

¹ Key Laboratory of the Ministry of Education for Medicinal Plant Resources and Natural Pharmaceutical Chemistry, National Engineering Laboratory for Resource Development of Endangered Crude Drugs in the Northwest of China, College of Life Sciences, Shaanxi Normal University, Xi'an, China.

Abstract

The human body generates 10-100 billion cells every day, and the same number of cells die to maintain homeostasis. The genetically controlled, autonomously ordered cell death mainly proceeds by apoptosis. Apoptosis is an important way of programmed cell death in multicellular organisms, timely and effective elimination of apoptotic cells plays a key role in the growth and development of organisms and the maintenance of homeostasis. During the clearance of apoptotic cells, transcription factors bind to specific target promoters and act as activators or repressors to regulate multiple genes expression, how transcription factors regulate apoptosis is an important and poorly understood aspect of normal development. This paper summarizes the regulatory mechanisms of transcription factors in the clearance of apoptotic cells to date.

Keywords: apoptosis; clearance of apoptotic cells; regulatory mechanisms; signal pathway; transcription factor.

Publication types

Review

Grants and funding

This work was partially supported by the National Natural Science Foundation of China (Grant No. 31871387 to HX), Natural Science Foundation of Shaanxi Province Youth Program, China (Grant No. 2022JQ-208 to QZ).