Association between sleep duration and quality with rapid kidney function decline and development of chronic kidney diseases in adults with normal kidney function: The China health and retirement longitudinal study

Sujuan Xu; Jifu Jin; Qi Dong; Chenjie Gu; Yong Wu; Haibo Zhang; Yingchao Yin; Huiyang Jia; Mingcheng Lei; Junfei Guo; Haixia Xu; Suchi Chang; Feng Zhang; Zhiyong Hou; Liping Zhang

doi:10.3389/fpubh.2022.1072238

Association between sleep duration and quality with rapid kidney function decline and development of chronic kidney diseases in adults with normal kidney function: The China health and retirement longitudinal study

Front Public Health. 2023 Jan 18:10:1072238. doi: 10.3389/fpubh.2022.1072238. eCollection 2022.

Authors

Sujuan Xu^{1

2

3}, Jifu Jin⁴, Qi Dong^{2

3}, Chenjie Gu⁵, Yong Wu^{6

7}, Haibo Zhang⁸, Yingchao Yin^{2

3}, Huiyang Jia^{2

3}, Mingcheng Lei⁹, Junfei Guo^{2

3}, Haixia Xu¹⁰, Suchi Chang¹¹, Feng Zhang⁹, Zhiyong Hou^{2

3}, Liping Zhang¹²

Affiliations

¹ Department of Nephrology, Third Hospital of Hebei Medical University, Shijiazhuang, China.
² Department of Orthopaedical Surgery, Third Hospital of Hebei Medical University, Shijiazhuang, China.
³ Orthopaedic Research Institute of Hebei Province, Hebei Medical University, Shijiazhuang, China.
⁴ Department of Cardiovascular Medicine, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, China.
⁵ The First Affiliated Hospital of Dalian Medical University, Dalian, China.
⁶ Department of Nephrology, Shanghai Ninth People's Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
⁷ Department of Nephrology, Huashan Hospital, Fudan University, Shanghai, China.
⁸ Department of Liver Disease, Affiliated Hospital of Shaanxi University of Chinese Medicine, Xianyang, Shaanxi, China.
⁹ Department of Rehabilitation Medicine, Third Hospital of Hebei Medical University, Shijiazhuang, China.
¹⁰ Department of Cardiology, Affiliated Hospital of Nantong University, Jiangsu, China.
¹¹ Department of Cardiology, Zhongshan Hospital, Shanghai Medical College, Fudan University, Shanghai, China.
¹² Department of Physiology, Hebei Medical University, Shijiazhuang, Hebei, China.

Abstract

Research have shown that sleep is associated with renal function. However, the potential effects of sleep duration or quality on kidney function in middle-aged and older Chinese adults with normal kidney function has rarely been studied. Our study aimed to investigate the association of sleep and kidney function in middle-aged and older Chinese adults. Four thousand and eighty six participants with an eGFR ≥60 ml/min/1.73 m² at baseline were enrolled between 2011 and 2015 from the China Health and Retirement Longitudinal Study. Survey questionnaire data were collected from conducted interviews in the 2011. The eGFR was estimated from serum creatinine and/or cystatin C using the Chronic Kidney Disease Epidemiology Collaboration equations (CKD-EPI). The primary outcome was defined as rapid kidney function decline. Secondary outcome was defined as rapid kidney function decline with clinical eGFR of <60 ml/min/1.73 m² at the exit visit. The associations between sleep duration, sleep quality and renal function decline or chronic kidney disease (CKD) were assessed based with logistic regression model. Our results showed that 244 (6.0%) participants developed rapid decline in kidney function, while 102 (2.5%) developed CKD. In addition, participants who had 3-7 days of poor sleep quality per week had higher risks of CKD development (OR 1.86, 95% CI 1.24-2.80). However, compared with those who had 6-8 h of night-time sleep, no significantly higher risks of rapid decline in kidney function was found among those who had <6 h or >8 h of night time sleep after adjustments for demographic, clinical, or psychosocial covariates. Furthermore, daytime nap did not present significant risk in both rapid eGFR decline or CKD development. In conclusion, sleep quality was significantly associated with the development of CKD in middle-aged and older Chinese adults with normal kidney function.

Keywords: aging; glomerular filtration rate; renal function decline; sleep duration; sleep quality.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Aged
Glomerular Filtration Rate
Humans
Kidney / physiopathology
Longitudinal Studies
Middle Aged
Renal Insufficiency, Chronic* / epidemiology
Sleep Duration*
Sleep Quality*

Grants and funding

This work was supported by National Natural Science Foundation of China (82072523 to ZH), National Natural Science Foundation of China (82200753 to SX).