Chemokines and chemokine receptors in Behçet's disease

Zhan Li; Linlin Cheng; Haoting Zhan; Yongzhe Li

doi:10.3389/fimmu.2023.1109147

Chemokines and chemokine receptors in Behçet's disease

Front Immunol. 2023 Jan 18:14:1109147. doi: 10.3389/fimmu.2023.1109147. eCollection 2023.

Authors

Zhan Li^{1

2}, Linlin Cheng^{1

2}, Haoting Zhan^{1

2}, Yongzhe Li^{1

2}

Affiliations

¹ Department of Clinical Laboratory, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, China.
² State Key Laboratory of Complex, Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, China.

Abstract

Behçet's disease (BD), a chronic vascular inflammatory disease, is characterized by the symptoms of ocular lesions, recurrent genital and oral ulcers, skin symptoms and arthritis in addition to neurological, intestinal and vascular involvement. The pathogenesis of BD is poorly understood, and there are no effective laboratory markers for the diagnosis of BD. In addition, BD is presently incurable. Chemokines, a family of small secreted chemotactic cytokines, interact with chemokine receptors and mediate the migration, localization and cellular interactions of inflammatory cells. Several studies have suggested that chemokines and their receptors play an important role in the occurrence and development of BD and that these chemokines along with their receptors can be utilized as biomarkers and therapeutic targets. In the present review, chemokines and chemokine receptors involved in BD and their potential application in diagnosis and therapy have been discussed.

Keywords: Behçet’s disease; cell infiltration; chemokine; chemokine receptor; therapeutic target.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Behcet Syndrome* / pathology
Chemokines
Humans
Intestines / pathology
Receptors, Chemokine

Substances

Receptors, Chemokine
Chemokines

Grants and funding

This work was supported by the National Key Research and Development Program of China (2018YFE0207300), the National Natural Science Foundation of China (81871302), and Beijing Key Clinical Specialty for Laboratory Medicine - Excellent Project (No. ZK201000).