Novel resorbable bone wax containing β-TCP and starch microspheres for accelerating bone hemostasis and promoting regeneration

Qiangqiang Duan; Huiling Liu; Lixia Zheng; Daozhang Cai; Guangxin Huang; Yu Liu; Rui Guo

doi:10.3389/fbioe.2023.1105306

Novel resorbable bone wax containing β-TCP and starch microspheres for accelerating bone hemostasis and promoting regeneration

Front Bioeng Biotechnol. 2023 Jan 19:11:1105306. doi: 10.3389/fbioe.2023.1105306. eCollection 2023.

Authors

Qiangqiang Duan¹, Huiling Liu¹, Lixia Zheng¹, Daozhang Cai^{2

3}, Guangxin Huang^{2

3}, Yu Liu¹, Rui Guo¹

Affiliations

¹ Guangzhou Beogene Biotech Co., Ltd., Guangzhou, China.
² Department of Joint Surgery and Sports Medicine, The Third Affiliated Hospital of Southern Medical University, Guangzhou, China.
³ The Third School of Clinical Medicine, Southern Medical University, Guangzhou, China.

Abstract

Traditional non-resorbable bone wax has been used in clinical surgery for more than 100 years. However, residual bone wax has been proven to cause numerous complications. In this study, a novel resorbable bone wax was designed to overcome the disadvantages of traditional non-resorbable bone wax. Alkylene oxide copolymers were used as the main component of resorbable bone wax; additionally, β-tricalcium phosphate and starch microspheres were added to enhance bone regeneration and hemostatic ability. This novel resorbable bone wax has a high potential for clinical translation and is expected to be developed as a substitute for traditional bone wax.

Keywords: alkylene oxide copolymers; bone regeneration and hemostatic; resorbable bone wax; starch microsphere; β-tcp.

Grants and funding

This study was supported by the National Foreign Experts Project Plan—“The Belt and Road” Innovative Talent Exchange Foreign Experts Project (DL2021031001L), the Key Areas Research and Development Program of Guangdong Province (2020B1111560001), the Key Areas Research and Development Program of Guangzhou (202103030003), the International Science and Technology Cooperation Project of Huangpu District/Guangzhou Development District (No. 2019GH11, No. 2020GH14, No. 2021GH16), the National Natural Science Foundation of China (81802187), and the Natural Science Foundation of Guangdong Province (2018030310355).