Severe Thrombocytopenia in a Patient With a History of Olfactory Neuroblastoma

Avani M Singh; Hailing Zhang; Lubomir Sokol

doi:10.7759/cureus.33297

Severe Thrombocytopenia in a Patient With a History of Olfactory Neuroblastoma

Cureus. 2023 Jan 3;15(1):e33297. doi: 10.7759/cureus.33297. eCollection 2023 Jan.

Authors

Avani M Singh^{1

2}, Hailing Zhang³, Lubomir Sokol²

Affiliations

¹ Hematology and Medical Oncology, University of South Florida, Tampa, USA.
² Hematology and Medical Oncology, Moffitt Cancer Center, Tampa, USA.
³ Pathology, Moffitt Cancer Center, Tampa, USA.

Abstract

Olfactory neuroblastoma is a rare disease with no randomized clinical trials to guide treatment decision making. Surgery, radiation, and chemotherapy are all used for treatment, and prognosis is mostly determined by the histologic grade and clinical stage. While a neuroendocrine type of neoplasm is similar to small cell carcinoma, metastatic disease in olfactory neuroblastoma is rare. We present a case at our institution of an uncommon clinical course of relapsed olfactory neuroblastoma complicated by severe thrombocytopenia.

Keywords: bone marrow; kadish; neuroendocrine; olfactory neuroblastoma; thrombocytopenia.

Publication types

Case Reports