Obesity-related heart failure with preserved ejection fraction: diagnostic and therapeutic challenges

Korean J Intern Med. 2023 Mar;38(2):157-166. doi: 10.3904/kjim.2022.271. Epub 2023 Feb 6.

Abstract

The prevalence of heart failure with preserved ejection fraction (HFpEF) has increased in recent decades. In particular, obesity-related HFpEF is a distinct and frequently encountered phenotype; however, its diagnosis is complex. Furthermore, the management of obesity-related HFpEF has not been established despite the introduction of promising drugs. This review summarizes the diagnostic challenges, pathophysiology, and therapeutic options for obesity-related HFpEF.

Keywords: Diagnosis; Dyspnea; Heart failure; Obesity; Treatment.

Publication types

  • Review

MeSH terms

  • Heart Failure* / diagnosis
  • Heart Failure* / etiology
  • Heart Failure* / therapy
  • Humans
  • Obesity / complications
  • Obesity / diagnosis
  • Obesity / epidemiology
  • Stroke Volume