TLR9 triggers MyD88-independent anti-inflammatory signaling in lupus

Trends Immunol. 2023 Mar;44(3):153-155. doi: 10.1016/j.it.2023.01.008. Epub 2023 Feb 3.

Abstract

Activation of Toll-like receptor 7 (TLR7) can induce lupus in mice, whereas activation of TLR9 can prevent it, even though both receptors interact with myeloid differentiation primary response gene 88 (MyD88) for downstream signaling. How TLR9 triggers anti-inflammatory responses in autoimmunity is unclear. Leibler et al. recently reported that TLR9 initiates anti-inflammatory signaling and inhibits lupus pathogenesis in a MyD88-independent but ligand-dependent manner.

Keywords: MyD88-independent; Toll-like receptor 9; age-associated B cell; anti-inflammation; autoimmunity.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adaptor Proteins, Signal Transducing
  • Animals
  • Anti-Inflammatory Agents
  • Mice
  • Mice, Knockout
  • Myeloid Differentiation Factor 88* / genetics
  • Myeloid Differentiation Factor 88* / metabolism
  • Signal Transduction
  • Toll-Like Receptor 7 / genetics
  • Toll-Like Receptor 7 / metabolism
  • Toll-Like Receptor 9* / metabolism

Substances

  • Toll-Like Receptor 9
  • Myeloid Differentiation Factor 88
  • Adaptor Proteins, Signal Transducing
  • Toll-Like Receptor 7
  • Anti-Inflammatory Agents
  • Myd88 protein, mouse
  • Tlr9 protein, mouse