Molecular genetic mechanisms of teratozoospermia

Zygote. 2023 Apr;31(2):101-110. doi: 10.1017/S0967199422000594. Epub 2023 Feb 6.

Abstract

In recent years, the incidence of teratospermia has been increasing, and it has become a very important factor leading to male infertility. The research on the molecular mechanism of teratospermia is also progressing rapidly. This article briefly summarizes the clinical incidence of teratozoospermia, and makes a retrospective summary of related studies reported in recent years. Specifically discussing the relationship between gene status and spermatozoa, the review aims to provide the basis for the genetic diagnosis and gene therapy of teratozoospermia.

Keywords: Gene; Male infertility; Spermatogenesis; Teratozoospermia.

Publication types

  • Review

MeSH terms

  • Humans
  • Infertility, Male* / genetics
  • Male
  • Molecular Biology
  • Retrospective Studies
  • Spermatozoa
  • Teratozoospermia* / genetics