Resting-state functional connectivity predicting clinical improvement following treatment in female adolescents with non-suicidal self-injury

Ines Mürner-Lavanchy; Johannes Josi; Julian Koenig; Corinna Reichl; Romuald Brunner; Michael Kaess

doi:10.1016/j.jad.2023.01.117

Resting-state functional connectivity predicting clinical improvement following treatment in female adolescents with non-suicidal self-injury

J Affect Disord. 2023 Apr 14:327:79-86. doi: 10.1016/j.jad.2023.01.117. Epub 2023 Feb 3.

Authors

Ines Mürner-Lavanchy¹, Johannes Josi¹, Julian Koenig², Corinna Reichl¹, Romuald Brunner³, Michael Kaess⁴

Affiliations

¹ University Hospital of Child and Adolescent Psychiatry and Psychotherapy, University of Bern, Switzerland.
² University Hospital of Child and Adolescent Psychiatry and Psychotherapy, University of Bern, Switzerland; University of Cologne, Faculty of Medicine and University Hospital Cologne, Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, Cologne, Germany.
³ Clinic and Policlinic of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, University of Regensburg, Germany.
⁴ University Hospital of Child and Adolescent Psychiatry and Psychotherapy, University of Bern, Switzerland; Department of Child and Adolescent Psychiatry, Centre for Psychosocial Medicine, University of Heidelberg, Germany. Electronic address: michael.kaess@upd.ch.

PMID: 36739001
DOI: 10.1016/j.jad.2023.01.117

Abstract

Background: Non-suicidal self-injury (NSSI) is highly prevalent among adolescents and predicts future psychopathology including suicide. To improve therapeutic decisions and clinical outcome of patients engaging in NSSI, it seems beneficial to determine neurobiological markers associated with treatment response. The present study investigated whether resting-state functional brain connectivity (RSFC) served to predict clinical improvements following treatment in adolescents engaging in NSSI.

Methods: N = 27 female adolescents with NSSI took part in a baseline MRI exam and clinical outcome was assessed at follow-ups one, two and three years after baseline. During the follow-up period, patients received in- and/or outpatient treatment. Mixed-effects linear regression models were calculated to examine whether RSFC was associated with clinical improvement.

Results: Patients' clinical outcome improved across time. Lower baseline RSFC between left paracentral gyrus and right anterior cingulate gyrus was associated with clinical improvement from baseline to one-year and from two-year to three-year follow-up. Lower and higher baseline RSFC in several inter- and intrahemispheric cortico-cortical and cortico-subcortical connections of interest were associated with clinical symptomatology and its severity, independent from time.

Limitations: A relatively small sample size constrains the generalizability of our findings. Further, no control group not receiving treatment was recruited, therefore clinical changes across time cannot solely be attributed to treatment.

Conclusions: While there was some evidence that RSFC was associated with clinical improvement following treatment, our findings suggest that functional connectivity is more predictive of severity of psychopathology and global functioning independent of time and treatment. We thereby add to the limited research on neurobiological markers as predictors of clinical outcome after treatment.

Keywords: Adolescents; Non-suicidal self-injury; Outcome; Psychological intervention; Resting-state connectivity; Therapy.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adolescent
Brain
Female
Frontal Lobe
Gyrus Cinguli
Humans
Magnetic Resonance Imaging
Self-Injurious Behavior*