From worms to humans: Understanding intestinal lipid metabolism via model organisms

Darby W Kozan; Joshua T Derrick; William B Ludington; Steven A Farber

doi:10.1016/j.bbalip.2023.159290

From worms to humans: Understanding intestinal lipid metabolism via model organisms

Biochim Biophys Acta Mol Cell Biol Lipids. 2023 Apr;1868(4):159290. doi: 10.1016/j.bbalip.2023.159290. Epub 2023 Feb 3.

Authors

Darby W Kozan¹, Joshua T Derrick¹, William B Ludington¹, Steven A Farber²

Affiliations

¹ Department of Biology, Johns Hopkins University, Baltimore, MD, United States; Department of Embryology, Carnegie Institute for Science, Baltimore, MD, United States.
² Department of Biology, Johns Hopkins University, Baltimore, MD, United States; Department of Embryology, Carnegie Institute for Science, Baltimore, MD, United States. Electronic address: farber@carnegiescience.edu.

Abstract

The intestine is responsible for efficient absorption and packaging of dietary lipids before they enter the circulatory system. This review provides a comprehensive overview of how intestinal enterocytes from diverse model organisms absorb dietary lipid and subsequently secrete the largest class of lipoproteins (chylomicrons) to meet the unique needs of each animal. We discuss the putative relationship between diet and metabolic disease progression, specifically Type 2 Diabetes Mellitus. Understanding the molecular response of intestinal cells to dietary lipid has the potential to undercover novel therapies to combat metabolic syndrome.

Keywords: Apolipoprotein B; Chylomicron; Drosophila; Fatty acid; Intestine; Lipids; Metabolic disease; Model organism; Zebrafish.

Publication types

Review

MeSH terms

Animals
Diabetes Mellitus, Type 2*
Dietary Fats / metabolism
Humans
Intestinal Absorption
Intestines
Lipid Metabolism* / physiology

Substances

Dietary Fats

Abstract

Publication types

MeSH terms

Substances

Grants and funding