Mechanotherapy in oncology: Targeting nuclear mechanics and mechanotransduction

Shaobao Liu; Yuan Li; Yuan Hong; Ming Wang; Hao Zhang; Jinlu Ma; Kai Qu; Guoyou Huang; Tian Jian Lu

doi:10.1016/j.addr.2023.114722

Mechanotherapy in oncology: Targeting nuclear mechanics and mechanotransduction

Adv Drug Deliv Rev. 2023 Mar:194:114722. doi: 10.1016/j.addr.2023.114722. Epub 2023 Feb 2.

Authors

Shaobao Liu¹, Yuan Li², Yuan Hong³, Ming Wang², Hao Zhang¹, Jinlu Ma⁴, Kai Qu⁵, Guoyou Huang⁶, Tian Jian Lu⁷

Affiliations

¹ State Key Laboratory of Mechanics and Control of Mechanical Structures, Nanjing University of Aeronautics and Astronautics, Nanjing 210016, PR China; MIIT Key Laboratory of Multifunctional Lightweight Materials and Structures, Nanjing University of Aeronautics, Nanjing 210016, PR China.
² MOE Key Laboratory of Biomedical Information Engineering, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an 710049, PR China; Bioinspired Engineering and Biomechanics Center (BEBC), Xi'an Jiaotong University, Xi'an 710049, PR China.
³ MOE Key Laboratory of Biomedical Information Engineering, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an 710049, PR China; Bioinspired Engineering and Biomechanics Center (BEBC), Xi'an Jiaotong University, Xi'an 710049, PR China; National Science Foundation Science and Technology Center for Engineering Mechanobiology, Washington University, St. Louis, MO 63130, USA.
⁴ Department of Radiation Oncology, the First Affiliated Hospital, Xian Jiaotong University, Xi'an 710061, PR China.
⁵ Department of Hepatobiliary Surgery, the First Affiliated Hospital, Xian Jiaotong University, Xi'an 710061, PR China.
⁶ Department of Engineering Mechanics, School of Civil Engineering, Wuhan University, Wuhan 430072, PR China. Electronic address: gyhuang@whu.edu.cn.
⁷ State Key Laboratory of Mechanics and Control of Mechanical Structures, Nanjing University of Aeronautics and Astronautics, Nanjing 210016, PR China; MIIT Key Laboratory of Multifunctional Lightweight Materials and Structures, Nanjing University of Aeronautics, Nanjing 210016, PR China. Electronic address: tjlu@nuaa.edu.cn.

PMID: 36738968
DOI: 10.1016/j.addr.2023.114722

Abstract

Mechanotherapy is proposed as a new option for cancer treatment. Increasing evidence suggests that characteristic differences are present in the nuclear mechanics and mechanotransduction of cancer cells compared with those of normal cells. Recent advances in understanding nuclear mechanics and mechanotransduction provide not only further insights into the process of malignant transformation but also useful references for developing new therapeutic approaches. Herein, we present an overview of the alterations of nuclear mechanics and mechanotransduction in cancer cells and highlight their implications in cancer mechanotherapy.

Keywords: Cancer cell; Mechanobiology; Mechanotherapy; Mechanotransduction; Nuclear mechanics.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Cell Nucleus
Humans
Mechanotransduction, Cellular*
Neoplasms*