Aim for zero: prevention of postoperative nausea and vomiting using an off-patent five-drug multimodal approach

Brian A Williams; Jennifer M Holder-Murray; John F Nettrour; James W Ibinson; Joseph S DeRenzo; Chelsee Dalessandro; Michael L Kentor; Andrew Herlich

doi:10.1016/j.bja.2023.01.005

Aim for zero: prevention of postoperative nausea and vomiting using an off-patent five-drug multimodal approach

Br J Anaesth. 2023 Jul;131(1):e1-e4. doi: 10.1016/j.bja.2023.01.005. Epub 2023 Feb 1.

Authors

Brian A Williams¹, Jennifer M Holder-Murray², John F Nettrour³, James W Ibinson⁴, Joseph S DeRenzo⁵, Chelsee Dalessandro⁶, Michael L Kentor⁵, Andrew Herlich⁵

Affiliations

¹ Department of Anesthesiology and Perioperative Medicine, University of Pittsburgh, Pittsburgh, PA, USA; Veterans Affairs Pittsburgh Healthcare System, Pittsburgh, PA, USA. Electronic address: williamsba@anes.upmc.edu.
² Department of Anesthesiology and Perioperative Medicine, University of Pittsburgh, Pittsburgh, PA, USA; Department of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA; Veterans Affairs Pittsburgh Healthcare System, Pittsburgh, PA, USA.
³ Veterans Affairs Pittsburgh Healthcare System, Pittsburgh, PA, USA; Department of Orthopaedic Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
⁴ Department of Anesthesiology and Perioperative Medicine, University of Pittsburgh, Pittsburgh, PA, USA; Veterans Affairs Pittsburgh Healthcare System, Pittsburgh, PA, USA.
⁵ Department of Anesthesiology and Perioperative Medicine, University of Pittsburgh, Pittsburgh, PA, USA.
⁶ Veterans Affairs Pittsburgh Healthcare System, Pittsburgh, PA, USA.

PMID: 36737386
DOI: 10.1016/j.bja.2023.01.005

No abstract available

Keywords: aprepitant; dexamethasone; diphenhydramine; opioid; pain management; palonosetron; perphenazine; postoperative complications; postoperative nausea and vomiting; treatment outcome.

Publication types

Letter

MeSH terms

Antiemetics* / therapeutic use
Dexamethasone / therapeutic use
Humans
Postoperative Nausea and Vomiting* / drug therapy
Postoperative Nausea and Vomiting* / prevention & control
Quinuclidines / therapeutic use
Vomiting

Substances

Antiemetics
Dexamethasone
Quinuclidines